Epi-isozizaene 5-monooxygenase (EC1.14.13.106,CYP170A1) is anenzyme withsystematic name(+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).^[1] This enzymecatalyses the followingchemical reaction

(+)-epi-isozizaene + 2 NADPH + 2 H⁺ + 2 O₂${\displaystyle \rightleftharpoons }$ albaflavenone + 2 NADP⁺ + 3 H₂O (overall reaction)

(1a) (+)-epi-isozizaene + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ (5S)-albaflavenol + NADP⁺ + H₂O

(1b) (5S)-albaflavenol + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ albaflavenone + NADP⁺ + 2 H₂O

(2a) (+)-epi-isozizaene + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ (5R)-albaflavenol + NADP⁺ + H₂O

(2b) (5R)-albaflavenol + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ albaflavenone + NADP⁺ + 2 H₂O

Thiscytochrome P450 enzyme is purified frombacteriumStreptomyces coelicolor.

• Epi-isozizaene+5-monooxygenase at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

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