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Eosinophil-derived neurotoxin

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

RNASE2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1GQV,1HI2,1HI3,1HI4,1HI5,1K2A,2BEX,2BZZ,2C01,2C02,2C05,5E13

Identifiers

Aliases

RNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2

External IDs

OMIM:131410;MGI:1858598;HomoloGene:121614;GeneCards:RNASE2;OMA:RNASE2 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q11.2	Start	20,955,487bp^[1]
Band	14q11.2	End	20,956,436bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 C1	Start	51,399,717bp^[2]
Band	14\|14 C1	End	51,400,475bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trabecular bone

bone marrow

bone marrow cell

monocyte

granulocyte

blood

right lung

spleen

germinal epithelium

right adrenal cortex

Top expressed in

skin of external ear

skin of abdomen

esophagus

skin of back

gastrula

cervix

perirhinal cortex

CA3 field

entorhinal cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nuclease activity endonuclease activity hydrolase activity ribonuclease A activity nucleic acid binding lipopolysaccharide binding ribonuclease activity lyase activity
Cellular component	extracellular region lysosome extracellular exosome azurophil granule lumen
Biological process	chemotaxis RNA catabolic process RNA phosphodiester bond hydrolysis, endonucleolytic positive regulation of protein targeting to mitochondrion neutrophil degranulation induction of bacterial agglutination defense response to Gram-negative bacterium defense response to Gram-positive bacterium RNA phosphodiester bond hydrolysis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


6036


54159

Ensembl


ENSG00000169385


ENSMUSG00000059606

UniProt


P10153


O35292

RefSeq (mRNA)


NM_002934


NM_019398

RefSeq (protein)


NP_002925


NP_062271

Location (UCSC)

Chr 14: 20.96 – 20.96 Mb

Chr 14: 51.4 – 51.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Eosinophil-derived neurotoxin is anenzyme that in humans is encoded by theRNASE2gene.^[5]^[6]^[7]

Theprotein encoded by this gene is found ineosinophil granulocytes. It is closely related to theeosinophil cationic protein (RNASE3) from which it diverged ~50 million years ago after the split between the old world and the new world monkeys.^[8] It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000169385 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000059606 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14".Genomics.13 (1):240–2.doi:10.1016/0888-7543(92)90237-M.PMID 1577491.
^Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989)."Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family".Proc Natl Acad Sci U S A.86 (12):4460–4.Bibcode:1989PNAS...86.4460R.doi:10.1073/pnas.86.12.4460.PMC 287289.PMID 2734298.
^"Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)".
^Rosenberg HF (2008-05-01)."RNase A ribonucleases and host defense: an evolving story".Journal of Leukocyte Biology.83 (5):1079–1087.doi:10.1189/jlb.1107725.ISSN 1938-3673.PMC 2692241.PMID 18211964.

External links

[edit]

RNASE2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
Eosinophil-Derived+Neurotoxin at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Eosinophil-derived neurotoxin

v t e PDB gallery
1gqv: ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN 1hi2: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) - SULPHATE COMPLEX 1hi3: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-2'-5'-DIPHOSPHATE COMPLEX 1hi4: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX 1hi5: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-5'-DIPHOSPHATE COMPLEX 1k2a: Modified Form of Eosinophil-derived Neurotoxin 2bex: CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION 2bzz: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A 2c01: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A 2c02: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A 2c05: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A

PDB gallery

1gqv: ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN
1hi2: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) - SULPHATE COMPLEX
1hi3: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-2'-5'-DIPHOSPHATE COMPLEX
1hi4: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX
1hi5: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-5'-DIPHOSPHATE COMPLEX
1k2a: Modified Form of Eosinophil-derived Neurotoxin
2bex: CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION
2bzz: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A
2c01: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A
2c02: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A
2c05: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A

Hydrolase:esterases (EC 3.1)

3.1.1:Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2:Thioesterase

3.1.3:Phosphatase

3.1.4:
Phosphodiesterase

3.1.6:Sulfatase

Nuclease (includes
deoxyribonuclease
andribonuclease)

3.1.11-16:
Exonuclease

Exodeoxyribonuclease	RecBCD
Exoribonuclease	Oligonucleotidase

3.1.21-31:
Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme;see{{Restriction enzyme}} UvrABC endonuclease
Endoribonuclease	RNase III Drosha:Microprocessor complex Dicer:RNA-induced silencing complex RNase H 1 2A 2B 2C RNase P RNase A RNase Z RNase E 1 2 3 4/5 RNase T1
either deoxy- or ribo-	Nuclease S1 Mung bean nuclease Serratia marcescens nuclease Micrococcal nuclease

Contents of thegranules ofgranulocytes

Azurophilic granules (1°)

Specific granules (2°)

Neutrophil	Alkaline phosphatase Lactoferrin Lysozyme NADPH oxidase Collagenase Cathelicidin
Eosinophil	Cathepsin Major basic protein Eosinophil cationic protein Eosinophil peroxidase Eosinophil-derived neurotoxin
Basophil	Heparin Histamine