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Envelysin (EC 3.4.24.12,sea-urchin-hatching proteinase,hatching enzyme,chorionase,chorion-digesting proteinase,chymostrypsin,sea urchin embryo hatching enzyme) is anenzyme.^[1]^[2]^[3]^[4] This enzymecatalyses the followingchemical reaction

Hydrolysis of proteins of thefertilization envelope anddimethylcasein

This enzyme is aglycoprotein from various members of the classEchinoidea.

References

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^Barrett D, Edwards BF (1976). "Hatching enzyme of the sea urchin Strongylocentrotus purpuratus".Part B: Proteolytic Enzymes. Methods in Enzymology. Vol. 45. pp. 354–73.doi:10.1016/s0076-6879(76)45032-2.ISBN 978-0-12-181945-3.PMID 1012003.
^Lepage T, Gache C (March 1989)."Purification and characterization of the sea urchin embryo hatching enzyme".The Journal of Biological Chemistry.264 (9):4787–93.doi:10.1016/S0021-9258(18)83659-6.PMID 2925668.
^Lepage T, Gache C (September 1990)."Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo".The EMBO Journal.9 (9):3003–12.doi:10.1002/j.1460-2075.1990.tb07493.x.PMC 552018.PMID 2167841.
^Nomura K, Tanaka H, Kikkawa Y, Yamaguchi M, Suzuki N (June 1991). "The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family".Biochemistry.30 (25):6115–23.doi:10.1021/bi00239a005.PMID 1711895.

External links

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Envelysin at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e Proteases:metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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