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| Clinical data | |
|---|---|
| Trade names | Baytril, others |
| AHFS/Drugs.com | International Drug Names |
| License data | |
| Pregnancy category | |
| Routes of administration | By mouth,subcutaneous,intramuscular |
| ATCvet code | |
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| Pharmacokinetic data | |
| Bioavailability | 80% in dogs, 65-75% in sheep[4] |
| Metabolism | Kidney and non-kidney[4] |
| Eliminationhalf-life | 4–5 hours in dogs, 6 hours in cats, 1.5 - 4.5 hours in sheep |
| Excretion | Bile duct (70%);kidney (30%)[5] |
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| DrugBank | |
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| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.131.355 |
| Chemical and physical data | |
| Formula | C19H22FN3O3 |
| Molar mass | 359.401 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 219 to 221 °C (426 to 430 °F) |
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Enrofloxacin, sold under the brand nameBaytril, among others, is afluoroquinolone antibiotic used for the treatment of animals.[1] It is abactericidal agent.[1]
The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for bothGram-negative andGram-positive bacteria and is active in both stationary and growth phases of bacterial replication. Enrofloxacin is partially deethylated by CYP450 into the active metaboliteciprofloxacin, which is also a fluoroquinolone antibiotic.
In September 2005, the FDA withdrew approval of enrofloxacin for use in water to treat flocks of poultry, as the practice was noted to promote the evolution of fluoroquinolone-resistant strains of the bacteriumCampylobacter, a human pathogen.[6] Enrofloxacin is available as afixed-dose combination medication withsilver sulfadiazine for the treatment of canine otitis externa.[7] It is available as ageneric medication.
Enrofloxacin is a synthetic antibacterial agent from the class of thefluoroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum ofGram-negative andGram-positive bacteria. It is effective against:
Variable activity against:
Ineffective against:
The following data represent minimum inhibitory concentration ranges for a few medically significant bacterial pathogens:
Enrofloxacin was banned for poultry use in the United States in 2005.[8]
It is unlikely that an acute overdose of either compound would result in symptoms more serious than either anorexia or vomiting, but the adverse effects noted above could occur. Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia. Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however.
In cats, enrofloxacin is retinotoxic and can produce sudden-onset blindness, often irreversible.[9][10][11][12][13]
The brown rot fungusGloeophyllum striatum can degrade the fluoroquinolone enrofloxacin using hydroxyl radicals.[14]
FDA Calls Efforts For Bayer Illegal
