Dual ET Receptor Antagonists, which affect bothendothelin A (ETA) andB receptors (ETB)[2]CPU0213 [821780-32-9] is an example of a dual receptor endothelin receptor antagonist.[3]
^Amberg W, Hergenröder S, Hillen H, Jansen R, Kettschau G, Kling A, et al. (1999). "Discovery and Synthesis of (S )-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist".Journal of Medicinal Chemistry.42 (16):3026–3032.doi:10.1021/jm9910425.PMID10447946.
^Wilhelm Amberg, et al. WO1998009953 (Abbott GmbH and Co KG).
^Jacks TE, Belmont DT, Briggs CA, Horne NM, Kanter GD, Karrick GL, et al. (March 2004). "Development of a scalable process for CI-1034, an endothelin antagonist".Organic Process Research & Development.8 (2):201–212.doi:10.1021/op034104g.
^Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, et al. (February 1994). "The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide".Journal of Medicinal Chemistry.37 (3):329–331.doi:10.1021/jm00029a001.PMID8308857.
^Murugesan N, Gu Z, Stein PD, Spergel S, Mathur A, Leith L, et al. (August 2000). "Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists".Journal of Medicinal Chemistry.43 (16):3111–3117.doi:10.1021/jm000105c.PMID10956219.
^US 5696116, Clozel JP, assigned to F Hoffmann La Roche AG
^Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, et al. (April 1995). "Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists".Journal of Medicinal Chemistry.38 (8):1259–1263.doi:10.1021/jm00008a002.PMID7731010.
^Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, et al. (June 1999). "Butenolide endothelin antagonists with improved aqueous solubility".Journal of Medicinal Chemistry.42 (12):2162–2168.doi:10.1021/jm980504w.PMID10377221.
^US 6288247, Andemichael YW, assigned to SmithKline Beecham Corp
^US 6022972, Devine PN, assigned to Merck and Co Inc
^Iwasaki T, Hayasaki-Kajiwara Y, Matsuo Y, Nakajima M (2001). "Endothelin receptor antagonist activity of (R)-(-)-2-(benzo[1,3]dioxol-5-yl)-N-(4-isopropylphenylsulfonyl)-2-(6-methyl- 2-propylpyridin-3-yloxy)acetamide hydrochloride (PABSA) in rat aortic smooth muscle cells and isolated rat thoracic aorta".Arzneimittel-Forschung.51 (7):529–534.doi:10.1055/s-0031-1300076.PMID11505783.
^WO 1995005376, Berryman KA, assigned to Warner Lambert Co LLC
^US 6448260, Cousins RD, assigned to SmithKline Beecham Corp
^WO 1996040681, Bradbury RH, assigned to AstraZeneca UK Ltd, Syngenta Ltd
