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Encainide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Encainide
Clinical data
Trade namesEnkaid
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa605040
ATC code
Legal status
Legal status
  • Withdrawn
Identifiers
  • 4-Methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H28N2O2
Molar mass352.478 g·mol−1
3D model (JSmol)
  • COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1
  • InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25) checkY
  • Key:PJWPNDMDCLXCOM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Encainide (trade nameEnkaid) is a class Icantiarrhythmic agent. It is no longer used because of its frequentproarrhythmic side effects.[1]

Synthesis

[edit]
Synthesis:[2]<

See also

[edit]

References

[edit]
  1. ^Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. (March 1991)."Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial".The New England Journal of Medicine.324 (12):781–8.doi:10.1056/NEJM199103213241201.PMID 1900101.
  2. ^Dykstra SJ, Minielli JL, Lawson JE, Ferguson HC, Dungan KW (September 1973). "Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines".Journal of Medicinal Chemistry.16 (9):1015–20.doi:10.1021/jm00267a012.PMID 4745503.
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