Inenzymology, anenamidase (EC3.5.2.18) is anenzyme thatcatalyzes thechemical reaction

6-oxo-1,4,5,6-tetrahydronicotinate + 2 H₂O${\displaystyle \rightleftharpoons }$ 2-formylglutarate + NH₃

Thus, the twosubstrates of this enzyme are6-oxo-1,4,5,6-tetrahydronicotinate andH₂O, whereas its twoproducts are2-formylglutarate andNH₃.

This enzyme belongs to the family ofhydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. Thesystematic name of this enzyme class is6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase.

• Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006)."Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri".Proc. Natl. Acad. Sci. U.S.A.103 (33):12341–6.Bibcode:2006PNAS..10312341A.doi:10.1073/pnas.0601635103.PMC 1562527.PMID 16894175.

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• Enzymes of unknown structure
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