Medical researcher
Emily Bernstein is a professor atMount Sinai School of Medicine known for her research onRNA interference ,epigenetics , and cancer, especiallymelanoma .
Education and career [ edit ] Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. fromStony Brook University in 2003.[ 1] Rockefeller University where she worked with David Allis.[ 2] [ 3]
Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzymeDicer , its role in cell development in mice,[ 4] RNA interference .[ 5] [ 6] [ 7] DNA methylation .[ 8] [ 9] [ 10] [ 11] [ 12] [ 13] [ 14] [ 15]
Selected publications [ edit ] Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001)."Role for a bidentate ribonuclease in the initiation step of RNA interference" .Nature .409 (6818):363– 366.doi :10.1038/35053110 .ISSN 0028-0836 .PMID 11201747 .S2CID 4371481 . Hammond, Scott M.; Bernstein, Emily; Beach, David; Hannon, Gregory J. (2000)."An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells" .Nature .404 (6775):293– 296.Bibcode :2000Natur.404..293H .doi :10.1038/35005107 .ISSN 0028-0836 .PMID 10749213 .S2CID 9091863 . Goldberg, Aaron D.; Allis, C. David; Bernstein, Emily (2007-02-23)."Epigenetics: A Landscape Takes Shape" .Cell .128 (4):635– 638.doi :10.1016/j.cell.2007.02.006 ISSN 0092-8674 .PMID 17320500 .S2CID 16604496 . Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01)."Dicer is essential for mouse development" .Nature Genetics .35 (3):215– 217.doi :10.1038/ng1253 .ISSN 1061-4036 .PMID 14528307 .S2CID 972721 . In 2014 Bernstein received a young investigators award from thePershing Square Foundation .[ 16]
^ "Speakers" . 2022-05-15. Archived fromthe original on 15 May 2022. Retrieved2022-05-15 .^ "Investigator | Bernstein Laboratory" .Bernstein Laboratory | . 2015-04-16. Retrieved2022-05-15 .^ "Emily Bernstein | Mount Sinai - New York" .Mount Sinai Health System . Retrieved2022-05-15 .^ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01)."Dicer is essential for mouse development" .Nature Genetics .35 (3):215– 217.doi :10.1038/ng1253 .ISSN 1061-4036 .PMID 14528307 .S2CID 972721 . ^ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001)."Role for a bidentate ribonuclease in the initiation step of RNA interference" .Nature .409 (6818):363– 366.doi :10.1038/35053110 .ISSN 0028-0836 .PMID 11201747 .S2CID 4371481 . ^ Bernstein, Emily; Allis, C. David (2005-07-15)."RNA meets chromatin" .Genes & Development .19 (14):1635– 1655.doi :10.1101/gad.1324305 ISSN 0890-9369 .PMID 16024654 . ^ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006)."Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin" .Molecular and Cellular Biology .26 (7):2560– 2569.doi :10.1128/MCB.26.7.2560-2569.2006 .ISSN 0270-7306 .PMC 1430336 PMID 16537902 . ^ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul; Lin, Shau-Ping; Allis, C. David; Cheng, Xiaodong (2007)."DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA" .Nature .448 (7154):714– 717.Bibcode :2007Natur.448..714O .doi :10.1038/nature05987 .ISSN 0028-0836 .PMC 2650820 PMID 17687327 . ^ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl; Valle-Garcia, David; Schaniel, Christoph; Lemischka, Ihor (2013-06-26)."MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency" .Nature Communications .4 (1): 1565.Bibcode :2013NatCo...4.1565G .doi :10.1038/ncomms2582 .ISSN 2041-1723 .PMC 4055026 PMID 23463008 . ^ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014)."Histone variants: emerging players in cancer biology" .Cellular and Molecular Life Sciences .71 (3):379– 404.doi :10.1007/s00018-013-1343-z .ISSN 1420-682X .PMC 4025945 PMID 23652611 . ^ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily; Lowe, Scott W. (2012-06-05)."H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence" .Proceedings of the National Academy of Sciences .109 (23):8971– 8976.Bibcode :2012PNAS..109.8971C .doi :10.1073/pnas.1119836109 ISSN 0027-8424 .PMC 3384172 PMID 22615382 . ^ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish; Zheng, Yang; Lam, Hung-Ming; Morrissey, Colm (2015)."NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes" .Nature Communications .6 (1): 6170.Bibcode :2015NatCo...6.6170S .doi :10.1038/ncomms7170 .ISSN 2041-1723 .PMC 4313575 PMID 25636082 . ^ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan; Wang, Zichen; Gallagher, Stuart J.; Hersey, Peter (2018)."SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling" .Nature Communications .9 (1): 3440.Bibcode :2018NatCo...9.3440S .doi :10.1038/s41467-018-05966-z .ISSN 2041-1723 .PMC 6109055 PMID 30143629 . ^ "Scientists discover gene mutation that signals aggressive melanoma" .ScienceDaily . April 6, 2022. Retrieved2022-05-15 .^ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali; Imig, Jochen; Martin, Tiphaine C.; Parsons, Ramon (2022-04-05)."Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma" .Cell Reports .39 (1): 110637.doi :10.1016/j.celrep.2022.110637 .ISSN 2211-1247 .PMC 9013128 PMID 35385731 . ^ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers".Crain's New York Business; New York . Vol. 30, no. 18. p. 22 – viaProQuest . 
