He shared theNobel Prize in Physiology or Medicine in 2014 with long-term collaborator and then-wifeMay-Britt Moser, and previous mentorJohn O'Keefe for their work identifying the brain's positioning system. The two main components of the brain's GPS are grid cells andplace cells, a specialized type of neuron that respond to specific locations in space. Together with May-Britt Moser he established theMoser research environment.
In 1996 he was appointed as associate professor inbiological psychology at the Department of Psychology at theNorwegian University of Science and Technology (NTNU); he was promoted to professor of neuroscience in 1998. In 2002, his research group was given the status of a separate "centre of excellence". Edvard Moser has led a succession of research groups and centres, collectively known as theMoser research environment.
Moser was born inÅlesund to German parents Eduard Paul Moser (1928–2013) and Ingeborg Annamarie Herholz (1931–). His parents had grown up inKronberg im Taunus, a suburb ofFrankfurt, where Moser's grandfather Eduard Moser had been Lutheran parish priest. Moser's father trained as apipe organ builder and emigrated to Norway together with his friend Jakob Pieroth in 1953 when they were offered employment at a pipe organ workshop atHaramsøy. They later established their own workshop and built many church pipe organs in Norway.[2][3] The Moser family originally was fromNassau;Moser is a South German topographic name for someone who lived near aswamp ormire (South GermanMoos).[4] Edvard Moser grew up atHareid and inÅlesund.[5][6][7] He was raised in a conservativeChristian family.[8]
Edvard Moser marriedMay-Britt Moser in 1985 when they were both students.[9] They announced that they are divorcing in 2016.[10]
Moser was awarded the cand.psychol. degree in psychology at theDepartment of Psychology at theUniversity of Oslo in 1990. He was then employed as a research fellow at the Faculty of Medicine, where he obtained hisdr.philos. doctoral research degree in the field ofneurophysiology in 1995.[12] He also has studied mathematics and statistics.[13] Early in his career, he worked under the supervision ofPer Andersen.
Moser returned to Norway in 1996 to be appointed associate professor in biological psychology at the Department of Psychology at the Norwegian University of Science and Technology (NTNU) in Trondheim. He was promoted to full professor of neuroscience in 1998. Moser is also head of department of the NTNU Institute for Systems Neuroscience.[citation needed]
Moser is founding director/co-director of threeResearch Council-funded centres of excellence:[15]
In 2005, he and his then-wifeMay-Britt Moser discoveredgrid cells[16] in the brain's medialentorhinal cortex. Grid cells are specialized neurons that provide the brain with a coordinate system and a metric for space. In 2018, he discovered a neural network that expresses a person's sense of time in experiences and memories located in the brain's lateralentorhinal cortex.[17]
He shared theNobel Prize in Physiology or Medicine in 2014 with long-term collaborator and then-wifeMay-Britt Moser, and previous mentorJohn O'Keefe for their work identifying the brain's positioning system. The two main components of the brain's GPS are; grid cells andplace cells,[18] a specialized type of neuron that respond to specific locations in space.[19][20] Together with May-Britt Moser he established theMoser research environment, which they lead.
Moser has been a member of the board of reviewing editors in science since 2004 and he has been reviewing editor forJournal of Neuroscience since 2005. He chaired the programme committee of the European Neuroscience meeting (FENS Forum) in 2006.[citation needed]
Moser, E.I., Mathiesen, I. & Andersen, P. (1993). Association between brain temperature and dentate field potentials in exploring and swimming rats.Science, 259, 1324–1326.
Brun, V.H., Otnæss, M.K., Molden, S., Steffenach, H.-A., Witter, M.P., Moser, M.-B., Moser, E.I. (2002). Place cells and place representation maintained by direct entorhinal-hippocampal circuitry.Science, 296, 2089–2284.
Fyhn, M., Molden, S., Witter, M.P., Moser, E.I. and Moser, M.-B. (2004). Spatial representation in the entorhinal cortex.Science, 305, 1258–1264Archived 17 February 2012 at theWayback Machine.
Leutgeb, S., Leutgeb, J.K., Treves, A., Moser, M.-B. and Moser, E.I. (2004). Distinct ensemble codes in hippocampal areas CA3 and CA1.Science, 305, 1295–1298.
Leutgeb, S., Leutgeb, J.K., Barnes, C.A., Moser, E.I., McNaughton, B.L., and Moser, M.-B (2005). Independent codes for spatial and episodic memory in the hippocampus.Science, 309, 619–623Archived 17 February 2012 at theWayback Machine.
Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., and Moser, E.I. (2005). Microstructure of a spatial map in the entorhinal cortex.Nature, 436, 801–806.
Colgin, L.L, and Moser, E.I. (2006). Rewinding the memory record.Nature, 440, 615–617.
Sargolini, F., Fyhn, M., Hafting, T., McNaughton, B.L., Witter, M.P., Moser, M.-B., and Moser, E.I. (2006). Conjunctive representation of position, direction and velocity in entorhinal cortex.Science, 312, 754–758.
Leutgeb, J.K., Leutgeb, S., Moser, M.-B., and Moser, E.I. (2007). Pattern separation in dentate gyrus and CA3 of the hippocampus.Science, 315, 961–966.
Fyhn, M., Hafting, T., Treves, A., Moser, M.-B. and Moser, E.I. (2007). Hippocampal remapping and grid realignment in entorhinal cortex.Nature, 446, 190–194.
Hafting, T., Fyhn, M., Bonnevie, T., Moser, M.-B. and Moser, E.I. (2008). Hippocampus-independent phase precession in entorhinal grid cells.Nature 453, 1248–1252.
Kjelstrup, K.B., Solstad, T., Brun, V.H., Hafting, T., Leutgeb, S., Witter, M.P., Moser, E.I. and Moser, M.-B. (2008). Finite scales of spatial representation in the hippocampus.Science 321, 140–143.
Solstad, T., Boccara, C.N., Kropff, E., Moser, M.-B. and Moser, E.I. (2008). Representation of geometric borders in the entorhinal cortex.Science, 322, 1865–1868.
Moser, E.I., Moser, M-B. (2011). Crystals of the brain. EMBO Mol. Med. 3, 1–4.
Moser, E.I., Moser, M-B. (2011). Seeing into the future. Nature, 469, 303–4
Jezek, K., Henriksen, EJ., Treves, A., Moser, E.I. and Moser, M-B. (2011). Theta-paced flickering between place-cell maps in the hippocampus. Nature, 478, 246–249.
Giocomo, LM., Moser, E.I., Moser, M-B. (2011) Grid cells use HCN1 channels for spatial scaling. Cell, 147, 1159–1170.
Igarashi, KM., Lu L., Colgin LL., Moser M-B., Moser EI. (2014) Coordination of entorhinal-hippocampal ensemble activity during associative learning.Nature 510, 143–7.
^Moser, M-B. (1995).Field potential changes in the dentate gyrus during spatial learning in the rat. Thesis for the degree of Dr. Philos., University of Oslo (defended on 9 December 1995).
^FENS Office (23 May 2013)."Moser, Edvard I."FENS.org. Archived fromthe original on 7 October 2014. Retrieved7 October 2014.
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