EGF-like module-containing mucin-like hormone receptor-like 3 is aprotein encoded by theADGRE3gene.[3][4] EMR3 is a member of theadhesion GPCR family.[5][6]Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing(GAIN) domain.[7]
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[8] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[9] Mice, next to Emr2, lack the Emr3 gene.[10]
^Stacey M, Yona S (2011).Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer.ISBN978-1-4419-7912-4.
