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EMPA (drug)

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Chemical compound

Pharmaceutical compound

EMPA
Clinical data

ATC code	none
Identifiers
IUPAC name N-Ethyl-N²-(6-methoxy-3-pyridinyl)-N²-[(2-methylphenyl)sulfonyl]-N-(3-pyridinylmethyl)glycinamide
CAS Number	680590-49-2^Y
PubChemCID	9981404
ChemSpider	8156996
UNII	VT87V86D7W
CompTox Dashboard(EPA)	DTXSID101045254
ECHA InfoCard	100.233.393
Chemical and physical data
Formula	C₂₃H₂₆N₄O₄S
Molar mass	454.55 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC1=CN=CC=C1)C(=O)CN(C2=CN=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3C
InChI InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3 Key:KJPHTXTWFHVJIG-UHFFFAOYSA-N

EMPA is a selectiveantagonist of theOX₂ receptor, with 900-foldselectivity in binding for OX₂ overOX₁.^[1]^[2]

^Malherbe P, Borroni E, Pinard E, Wettstein JG, Knoflach F (September 2009). "Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists".Molecular Pharmacology.76 (3):618–31.doi:10.1124/mol.109.055152.PMID 19542319.S2CID 5702143.
^Malherbe P, Borroni E, Gobbi L, Knust H, Nettekoven M, Pinard E, et al. (April 2009)."Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor".British Journal of Pharmacology.156 (8):1326–41.doi:10.1111/j.1476-5381.2009.00127.x.PMC 2697736.PMID 19751316.

v t e Orexin receptor modulators
OX₁	Agonists:AEX-5 AEX-19 AEX-24 Orexin (A,B) Antagonists:ACT-335827 ACT-462206 Almorexant AZD-4041 C4X-3256 (INDV-2000) CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142)
OX₂	Agonists:AEX-19 Alixorexton ALKS-2680 Danavorexton (TAK-925) E-2086 Firazorexton (TAK-994) Orexin (A,B) Oveporexton (TAK-861) SB-668875 Suntinorexton Antagonists:ACT-335827 ACT-462206 Almorexant Daridorexant EMPA Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)

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