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EIF4A3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

EIF4A3

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2HXY,2HYI,2J0Q,2J0S,2J0U,2XB2,3EX7,4C9B

Identifiers

Aliases

EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, eIF4A-III, eIF-4A-III

External IDs

OMIM:608546;MGI:1923731;HomoloGene:5602;GeneCards:EIF4A3;OMA:EIF4A3 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.3	Start	80,134,369bp^[1]
Band	17q25.3	End	80,147,151bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	119,179,189bp^[2]
Band	11\|11 E2	End	119,190,915bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

beta cell

gonad

left uterine tube

mucosa of pharynx

olfactory bulb

ventricular zone

mucosa of esophagus

mucosa of urinary bladder

gingival epithelium

left ovary

Top expressed in

morula

epiblast

embryo

primary oocyte

embryo

neural tube

ventricular zone

thymus

mesencephalon

spleen

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding selenocysteine insertion sequence binding helicase activity poly(A) binding RNA stem-loop binding protein binding nucleic acid binding ribonucleoprotein complex binding hydrolase activity ATP binding mRNA binding RNA binding translation regulator activity
Cellular component	cytoplasm cytosol nuclear speck catalytic step 2 spliceosome membrane exon-exon junction complex soma dendrite spliceosomal complex nucleus nucleoplasm nucleolus glutamatergic synapse postsynaptic cytosol ribonucleoprotein complex U2-type catalytic step 1 spliceosome
Biological process	nuclear-transcribed mRNA poly(A) tail shortening mRNA transport negative regulation of translation associative learning response to organic cyclic compound regulation of mRNA binding mRNA processing positive regulation of translation negative regulation of gene expression negative regulation of excitatory postsynaptic potential cellular response to brain-derived neurotrophic factor stimulus cellular response to selenite ion exploration behavior RNA secondary structure unwinding RNA splicing rRNA processing embryonic cranial skeleton morphogenesis negative regulation of selenocysteine insertion sequence binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translation negative regulation of selenocysteine incorporation mRNA splicing, via spliceosome RNA export from nucleus termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing positive regulation of transcription by RNA polymerase II positive regulation of mRNA splicing, via spliceosome transport regulation of translation at postsynapse, modulating synaptic transmission
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9775


192170

Ensembl


ENSG00000141543


ENSMUSG00000025580

UniProt


P38919


Q91VC3

RefSeq (mRNA)


NM_014740


NM_138669

RefSeq (protein)


NP_055555


NP_619610

Location (UCSC)

Chr 17: 80.13 – 80.15 Mb

Chr 11: 119.18 – 119.19 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Eukaryotic initiation factor 4A-III is aprotein that in humans is encoded by theEIF4A3gene.^[5]^[6]^[7]

Function

[edit]

This gene encodes a member of theDEAD box protein family. DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putativeRNA helicases. They are implicated in a number of cellular processes involving alteration ofRNA secondary structure, such astranslation initiation, nuclear and mitochondrialsplicing, andribosome andspliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved inembryogenesis,spermatogenesis, andcellular growth and division. The protein encoded by this gene is anuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of thetranslation initiation factors eIF4A-I andeIF4A-II, two other members of the DEAD box protein family.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000141543 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025580 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, et al. (Feb 2000). "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A".Biochem Biophys Res Commun.267 (1):339–44.doi:10.1006/bbrc.1999.1973.PMID 10623621.
^Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, et al. (Jan 2004)."eIF4A3 is a novel component of the exon junction complex".RNA.10 (2):200–9.doi:10.1261/rna.5230104.PMC 1370532.PMID 14730019.
^^a ^b"Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3".

Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (1995)."Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1".DNA Res.2 (1):37–43.doi:10.1093/dnares/2.1.37.PMID 7788527.
Li Q, Imataka H, Morino S, Rogers Jr GW, Richter-Cook NJ, Merrick WC, et al. (1999)."Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII".Mol. Cell. Biol.19 (11):7336–46.doi:10.1128/mcb.19.11.7336.PMC 84727.PMID 10523622.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002)."Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis".RNA.8 (4):426–39.doi:10.1017/S1355838202021088.PMC 1370266.PMID 11991638.
Lee S, Baek M, Yang H, Bang YJ, Kim WH, Ha JH, et al. (2002). "Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays".Cancer Lett.184 (2):197–206.doi:10.1016/S0304-3835(02)00197-0.PMID 12127692.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay".Nature.427 (6976):753–7.Bibcode:2004Natur.427..753P.doi:10.1038/nature02351.PMID 14973490.S2CID 4400243.
Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, et al. (2004)."A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay".Proc. Natl. Acad. Sci. U.S.A.101 (12):4118–23.Bibcode:2004PNAS..101.4118F.doi:10.1073/pnas.0400933101.PMC 384704.PMID 15024115.
Shibuya T, Tange TØ, Sonenberg N, Moore MJ (2004)."eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay".Nat. Struct. Mol. Biol.11 (4):346–51.doi:10.1038/nsmb750.PMID 15034551.S2CID 30171314.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (2004)."Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization".Curr. Biol.14 (16):1436–50.Bibcode:2004CBio...14.1436J.doi:10.1016/j.cub.2004.07.051.PMID 15324660.S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (2005). "Nucleolar proteome dynamics".Nature.433 (7021):77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID 15635413.S2CID 4344740.
Xia Q, Kong XT, Zhang GA, Hou XJ, Qiang H, Zhong RQ (2005). "Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer".Biochem. Biophys. Res. Commun.330 (2):526–32.doi:10.1016/j.bbrc.2005.02.181.PMID 15796914.
Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, Le Hir H (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity".Nat. Struct. Mol. Biol.12 (10):861–9.doi:10.1038/nsmb990.PMID 16170325.S2CID 1359792.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, et al. (2005)."Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements".Mol. Cell.20 (1):65–75.doi:10.1016/j.molcel.2005.08.012.PMID 16209946.
Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA".Science.313 (5795):1968–72.Bibcode:2006Sci...313.1968A.doi:10.1126/science.1131981.PMID 16931718.S2CID 26409491.
You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, et al. (2007)."Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors".PLOS Biol.5 (5): e109.doi:10.1371/journal.pbio.0050109.PMC 1854916.PMID 17456004.
Zhang Z, Krainer AR (2007)."Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components".Proc. Natl. Acad. Sci. U.S.A.104 (28):11574–9.Bibcode:2007PNAS..10411574Z.doi:10.1073/pnas.0704946104.PMC 1913901.PMID 17606899.

v t e PDB gallery
2hxy: Crystal structure of human apo-eIF4AIII 2hyi: Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA 2j0q: THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 3.2 A RESOLUTION 2j0s: THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 2.2 A RESOLUTION 2j0u: THE CRYSTAL STRUCTURE OF EIF4AIII-BARENTSZ COMPLEX AT 3.0 A RESOLUTION

Protein biosynthesis:translation (bacterial,archaeal,eukaryotic)

Proteins

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X,RPS4Y1,RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Retrieved from "https://en.wikipedia.org/w/index.php?title=EIF4A3&oldid=1300835492"

Category:

Genes on human chromosome 17

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Function

References

Further reading