Ephrin-B2 is aprotein that in humans is encoded by theEFNB2gene.[5]
This gene encodes a member of theephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and inerythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to theEPHB4 andEPHA3 receptors.[6]
EFNB2 gene has been observed progressively downregulated inHuman papillomavirus-positiveneoplastic keratinocytes derived from uterine cervicalpreneoplastic lesions at different levels of malignancy.[7] For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervicalpreneoplastic lesions progression.[7]
EFNB2 has been shown tointeract withEPHA3[8][9] andEPHB1 inoptic chiasm development.[10]
EFNB2 has also been shown to serve as a receptor forHendra Virus and Nipah Virus, mediatingentry into the cell during infection.[11]
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