Ephrin-A2 is aprotein that in humans is encoded by theEFNA2gene.[5]
This gene encodes a member of theephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily ofreceptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into theephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and theephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[5]
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