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| Content | |
|---|---|
| Data types captured | Protein domains |
| Contact | |
| Research center | Grishin Lab,University of Texas Southwestern Medical Center |
| Authors | H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin. |
| Primary citation | PMID 25474468 |
| Release date | 2014 |
| Access | |
| Website | http://prodata.swmed.edu/ecod/ |
| Miscellaneous | |
| Version | continuously updated |
| Curation policy | manual for new proteins; automated for ones with close matches |
TheEvolutionary Classification of Protein Domains (ECOD) is abiological database that classifiesprotein domains available from theProtein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins.
Similar toPfam,CATH, andSCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins byfolds, which may simply representconvergent evolution, ECOD groups proteins by demonstratablehomology only.[1]
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