The protein encoded by this gene is a member of the E2F family oftranscription factors. The E2F family plays a crucial role in the control ofcell cycle and action oftumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members,E2F1 andE2F3, have an additionalcyclin binding domain. This protein binds specifically toretinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[7]
^Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein".Mol. Endocrinol.16 (8):1727–37.doi:10.1210/me.2001-0353.PMID12145330.S2CID14975453.
Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members".J. Cell Sci.109 (7):1717–26.doi:10.1242/jcs.109.7.1717.PMID8832394.
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G (2001). "The E2F1-3 transcription factors are essential for cellular proliferation".Nature.414 (6862):457–62.Bibcode:2001Natur.414..457W.doi:10.1038/35106593.PMID11719808.S2CID3062825.
Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)".Eur. J. Biochem.268 (23):6076–82.doi:10.1046/j.0014-2956.2001.02555.x.PMID11733001.
Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein".Mol. Endocrinol.16 (8):1727–37.doi:10.1210/me.2001-0353.PMID12145330.S2CID14975453.
