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Drugs secreted in the kidney

From Wikipedia, the free encyclopedia

This is a table ofdrugs that aresecreted in thekidney.

Acid medication are, because ofpH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

MedicationLocationAcid orbase[1]anion orcation[2]Percentage excreted[3]
para-aminohippurateproximal tubule[4]Acidanion
furosemideproximal tubule[4]Acidanion100-75
glucuronic acid-conjugatesproximal tubule[4]Acid
glycine conjugatesproximal tubule[4]Acid
indometacinproximal tubule[4]Acidanion
methotrexateproximal tubule[4]Acid100-75
penicillinproximal tubule[4]Acidanion75-50
(benzylpenicillin)
probenecidproximal tubule[4]Acidanion
sulphate conjugatesproximal tubule[4]Acid
thiazide diureticsproximal tubule[4]Acid
uric acidproximal tubule[4]Acid
amilorideproximal tubule[4]Basecation
dopamineproximal tubule[4]Base
histamineproximal tubule[4]Base
mepacrineproximal tubule[4]Base
morphineproximal tubule[4]Basecation
pethidineproximal tubule[4]Base
quaternary ammonium compoundsproximal tubule[4]Base
quinineproximal tubule[4]Basecation
5-hydroxytryptamine (serotonin)proximal tubule[4]Base
triamtereneproximal tubule[4]Base
gentamicin100-75
atenolol100-75
digoxin100-75
cimetidinecation75-50
tetracycline75-50
(oxytetracycline)
neostigmine75-50
propantheline~50
tubocurarine~50
acetazolamideproximal tubule[5]anion
chlorothiazideproximal tubule[5]anion
saccharinproximal tubule[5]anion
salicylateproximal tubule[5]anion
atropineproximal tubule[5]cation
NMNproximal tubule[5]cation
paraquatproximal tubule[5]cation
procainamideproximal tubule[5]cation
tetraethylammoniumproximal tubule[5]cation
chlorpromazineproximal tubule[5]cation

References

[edit]
  1. ^Unless else specified in table boxes, then ref isRang, H. P. (2003).Pharmacology. Edinburgh: Churchill Livingstone.ISBN 0-443-07145-4. Page 112
  2. ^Unless else specified in table boxes, then ref isWalter F., PhD. Boron.Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders.ISBN 1-4160-2328-3. Page 802
  3. ^Unless else specified in table boxes, then ref isRang, H. P. (2003).Pharmacology. Edinburgh: Churchill Livingstone.ISBN 0-443-07145-4. Page 113
  4. ^abcdefghijklmnopqrstuRang, H. P. (2003).Pharmacology. Edinburgh: Churchill Livingstone.ISBN 0-443-07145-4. Page 112
  5. ^abcdefghijWalter F., PhD. Boron.Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders.ISBN 1-4160-2328-3. Page 802
Creatingurine
Secretion
Reabsorption
Filtration
Other functions
Hormones
Fluid balance
Acid–base balance
Assessment and measurement
Other
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