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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| ECHA InfoCard | 100.067.468 |
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| Formula | C11H14N4O4 |
| Molar mass | 266.257 g·mol−1 |
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Doxofylline (also known asdoxophylline) is aphosphodiesterase inhibitingbronchodilator used in the treatment of chronic respiratory diseases such asasthma[1] andCOPD.[2] Liketheophylline, it is axanthine derivative.[3][4]
Doxophylline is used to treat chronic respiratory diseases such asasthma[1] andCOPD.[2]
In animal and human studies, it has shown similar efficacy totheophylline but with significantly fewer side effects.[5] In February 2014, the USFDA granted anorphan drug designation to doxofylline for the treatment ofbronchiectasis following the submission of an application by Alitair Pharmaceuticals, in May 2013.[6][7][8]
Unlike other xanthines, doxofylline lacks any significantaffinity foradenosine receptors and does not producestimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions onphosphodiesterase.[1] From apharmacokinetic point of view, doxofylline importantly differs from theophylline also because it lacks the ability to interfere with the cytochrome enzymesCYP1A2,CYP2E1 andCYP3A4, thus preventing significant interaction with other drugs metabolized via these pathways in the liver.[9][10]
Concomitant treatment with certain other medications (includingallopurinol,H2 receptor antagonists,lincosamide antibiotics,macrolide antibiotics, andpropranolol) can decrease the hepatic clearance of doxofylline, which can result in increased serum levels of doxofylline.
It is marketed under many brand names worldwide, including: Xiva, An Li Nuo Er, An Sai Ma, Ansimar, Asima, Bestofyline, Chuan Ning, D-Fyal, Dilatair, Doxiba, Doxiva, Doxobid, Doxobron, Doxofilina, Doxofillina, Doxofyllin, Doxoll, Doxophylline, Doxovent, Doxyjohn, Fei Te Ai Si, Fixolin, Jian Fang Neng, Lang Ming, Lv Meng, Mai Ping Xi, Maxivent, Mucosma, Na De Lai, Phylex, Phyllin, Puroxan, Rexipin, Shu Zhi, Shuai An, Shuweixin, Suo Di, Suo Ji, Suo Li An, Xi Si Nuo, Xin Qian Ping, Xin Xi Ping, Yi Suo, and Yili.[11]
It is also marketed as acombination drug withterbutaline as Doxoll-TL, Mucosma-T and Phylex-TR.[11] It is also marketed as a combination drug withmontelukast as Doxoll-ML, Doxomont, Doxoril-M, Doxovent-M, Lunair-M, and Venidox-M.[11]
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