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| Names | |
|---|---|
| IUPAC name (RS)-2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol | |
| Other names UCB-3412 | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider |
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| ECHA InfoCard | 100.017.811 |
| EC Number |
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| KEGG |
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| UNII | |
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| Properties | |
| C24H33N3O2S | |
| Molar mass | 427.60272 g/mol |
| Pharmacology | |
| N05AB01 (WHO) | |
| Legal status | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Dixyrazine, also known asdixypazin (oxalate), sold under the brand namesAnsiolene,Esocalm,Esucos,Metronal, andRoscal, is atypical antipsychotic of thephenothiazine group described as aneuroleptic andantihistamine.[2] It was first introduced in Germany in 1969. It is used as a neuroleptic,anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day.
Sodamide alkylation ofphenothiazine (1) with 1-bromo-3-chloro-2-methylpropane (2) gives 10-(3-Chloro-2-methylpropyl)phenothiazine (3).[3][4] Completion of the sidechain by alkylation with 1-[2-(2-hydroxyethoxy)ethyl]piperazine (4) and displacement of the halogen completes the synthesis of dixyrazine (5).
