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| Formula | C25H28N2O2 |
| Molar mass | 388.511 g·mol−1 |
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Diphenpipenol is anopioidanalgesic drug invented in the 1970s byDainippon Pharmaceutical Co.[1] It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such asMT-45 andAD-1211, but diphenpipenol is the most potent compound in the series, with the more active(S) enantiomer being around 105 times the potency ofmorphine in animal studies.[2] This makes it a similar strength tofentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threateningrespiratory depression, as well as other typical opioid side effects such assedation,itching,nausea andvomiting.
Diphenpipenol has been offered for sale online as adesigner drug, though analysis of a sample of supposed diphenpipenol found it to instead contain a structural isomer with much weaker opioid activity, and it is unclear if genuine diphenpipenol has actually been sold.[3]
