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Dinoxyline

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Chemical compound

Pharmaceutical compound

Dinoxyline
Clinical data

ATC code	none
Identifiers
IUPAC name 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline
CAS Number	757176-96-8^Y
PubChemCID	9819126
ChemSpider	7994875
UNII	9T7B8CV47A
CompTox Dashboard(EPA)	DTXSID801028590
Chemical and physical data
Formula	C₁₅H₁₃NO₃
Molar mass	255.273 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c3ccc(Oc24)c1c3CNCC1c4ccc(O)c2O
InChI InChI=1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2 Key:QOHSTVKJXZTEOL-UHFFFAOYSA-N
(verify)

Dinoxyline is asynthetic compound developed for scientific research, which acts as a potentfull agonist at all fivedopamine receptor subtypes.^[1]^[2]^[3]

^Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms".Bioorganic & Medicinal Chemistry.12 (6):1403–12.doi:10.1016/j.bmc.2004.01.008.PMID 15018913.
^Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists".Molecular Pharmacology.68 (4):1039–48.doi:10.1124/mol.105.012153.PMID 15985612.S2CID 14398107.
^Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going".Medicinal Research Reviews.29 (2):272–94.doi:10.1002/med.20130.PMID 18642350.S2CID 25334596.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

Agonists

Antagonists

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