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Dimethyltubocurarine chloride

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(Redirected fromDimethyltubocurarine)
Chemical compound

Pharmaceutical compound
Dimethyltubocurarine chloride
Clinical data
Other names(+)-O,O'-dimethyl-tubocurine dichloride
ATC code
Identifiers
  • (1S,16R)-9,10,21,25-Tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaene-15,30-diium dichloride
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.046.768Edit this at Wikidata
Chemical and physical data
FormulaC40H48Cl2N2O6
Molar mass723.73 g·mol−1
3D model (JSmol)
  • C[N+]1(CCc2cc(c3cc2[C@@H]1Cc4ccc(cc4)Oc5c6c(cc(c5OC)OC)CC[N+]([C@@H]6Cc7ccc(c(c7)O3)OC)(C)C)OC)C.[Cl-].[Cl-]
  • InChI=1S/C40H48N2O6.2ClH/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1
  • Key:IRPSJVWFSWAZSZ-OIUSMDOTSA-L
 ☒NcheckY (what is this?)  (verify)

Dimethyltubocurarine chloride (INN; also known asmetocurine chloride (USAN) is a non-depolarizingnicotinic acetylcholine receptorantagonist used as amuscle relaxant.[1][2]

References

[edit]
  1. ^United States Public Health Service (1965).Public Health Service Publication. U.S. Department of Health, Education, and Welfare, Public Health Service, Environmental Health Service, National Air Pollution Control Administration. p. 126.
  2. ^Savarese JJ, Ali HH, Antonio RP (September 1977). "The clinical pharmacology of metocurine: dimethyltubocurarine revisited".Anesthesiology.47 (3):277–84.doi:10.1097/00000542-197709000-00009.PMID 70179.
Peripherally acting
(primarilyantinicotinic,
NMJ block)
Non-depolarizing
Curarealkaloids
4° ammonium agents
Depolarizing
ACh release inhibitors
Centrally acting
Carbamic acid esters
Benzodiazepines
Nonbenzodiazepines
Thienodiazepines
Quinazolines
Anticholinergics
(Antimuscarinics)
Other
Directly acting
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(andPAMsTooltip positive allosteric modulators)
Antagonists
(andNAMsTooltip negative allosteric modulators)
Precursors
(andprodrugs)
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