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Tiapamil

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(Redirected fromDimeditiapramine)
Chemical compound
Pharmaceutical compound
Tiapamil
Clinical data
Other namesDimeditiapramine; Ro 11-1781
Identifiers
  • 2-(3,4-Dimethoxyphenyl)-2-(3-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}propyl)-1λ6,3λ6-dithiane-1,1,3,3-tetrone
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.054.992Edit this at Wikidata
Chemical and physical data
FormulaC26H37NO8S2
Molar mass555.70 g·mol−1
3D model (JSmol)
  • CN(CCCC1(S(=O)(=O)CCCS1(=O)=O)C2=CC(=C(C=C2)OC)OC)CCC3=CC(=C(C=C3)OC)OC

Tiapamil (INN; also known asdimeditiapramine) is a calcium antagonist orcalcium channel blocker.[1][2] It is an experimental drug that has never been marketed.[3]

Tiapamil has been described as anantianginal agent. It exhibits properties of anti-arrhythmic medications. These are medications that are used to treat unusually fast or irregular heartbeats. Examples of arrhytmthic conditions includeatrial fibrillation,atrial flutter, andsuper-ventricular tachycardia.[4] Upon research, the drug shows promising effects on treatment of these condition. Research seeks to create a treatment with tiapamil in order to mitigate the side effects of the more commonly prescribed calcium antagonist and anti-hypertensiveverapamil. The two drugs have similar properties; however, tiapamil appears to treat arrhythmic conditions without many of the hypotensive, negative inotropic, and negative chronotropic side effects. Tiapamil is a calcium channel blocker that acts on the slow calcium channels. It can treat ventricular arrhythmias to a higher degree than traditional calcium antagonists.[medical citation needed]

See also

[edit]

References

[edit]
  1. ^Cocco G, Strozzi C, Chu D (June 1979). "Human electropharmacology of the calcium antagonist dimeditiapramine (Ro 11-1781) in coronary patients".Clinical Cardiology.2 (3):212–216.doi:10.1002/clc.4960020307.PMID 509799.S2CID 24609271.
  2. ^Nowak FG, Cocco G, Chu D, Gasser DF (December 1980)."Antiarrhythmic effect of the calcium antagonist tiapamil (Ro 11-1781) by intravenous administration in patients with coronary heart disease".Clinical Cardiology.3 (6):371–376.doi:10.1002/clc.4960030603.PMID 6161729.S2CID 196402596.
  3. ^"Tiapamil".AdisInsight. Springer Nature Switzerland AG.
  4. ^Cocco G, Chu D, Strozzi C (April 1979). "Dimeditiapramine (Ro 11-1781), a new calcium antagonist, in the management of supraventricular tachyarrhythmias in patients with acute myocardial infarction".Clinical Cardiology.2 (2):131–134.doi:10.1002/clc.4960020208.PMID 262567.S2CID 38589956.
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
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