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Dihydrofolic acid

Names
IUPAC name N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
Other names H2folate, DH
Identifiers
CAS Number	4033-27-6 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:15633 Y
ChEMBL	ChEMBL46294 Y
ChemSpider	89228 Y
ECHA InfoCard	100.116.435
MeSH	dihydrofolate
PubChemCID	98792
UNII	KXP0KNM559 Y
CompTox Dashboard(EPA)	DTXSID401027140
InChI InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Y Key: OZRNSSUDZOLUSN-LBPRGKRZSA-N Y InChI=1/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 Key: OZRNSSUDZOLUSN-LBPRGKRZBB
SMILES O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC/2=N/C=3C(=O)\N=C(/NC=3NC\2)N)CCC(=O)O
Properties
Chemical formula	C19H21N7O6
Molar mass	443.414 g/mol
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Dihydrofolic acid (conjugate basedihydrofolate) (DHF) is afolic acid (vitamin B₉) derivative which is converted totetrahydrofolic acid bydihydrofolate reductase.^[1] Since tetrahydrofolate is needed to make bothpurines andpyrimidines, which are building blocks ofDNA andRNA, dihydrofolate reductase is targeted by various drugs to preventnucleic acid synthesis.

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activityedit]]

Fluorouracil (5-FU) Activityedit

1. ^The interactive pathway map can be edited at WikiPathways:"FluoropyrimidineActivity_WP1601".

• Gangjee, Aleem; Jain, Hiteshkumar D.; Kurup, Sonali (2007). "Recent Advances in Classical and Non-Classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part I".Anti-Cancer Agents in Medicinal Chemistry.7 (5):524–542.doi:10.2174/187152007781668724.PMID 17896913.

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