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| Trade names | Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Cycladiene, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol |
| Other names | Dienoestrol;p-[(E,E)-1-Ethylidene-2-(p-hydroxyphenyl)-2-butenyl]phenol; 3,4-Di(para-hydroxyphenyl)-2,4-hexadiene |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Drug class | Nonsteroidal estrogen |
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| ECHA InfoCard | 100.001.381 |
| Chemical and physical data | |
| Formula | C18H18O2 |
| Molar mass | 266.340 g·mol−1 |
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Dienestrol (INNTooltip International Nonproprietary Name,USANTooltip United States Adopted Name) (brand namesDienoestrol,Denestrolin,Dienol and many others[a]), also known asdienoestrol (BANTooltip British Approved Name), is asyntheticnonsteroidal estrogen medication of thestilbestrol group which is or was used to treatmenopausal symptoms in theUnited States andEurope.[1][2][3][4] It has been studied for use byrectal administration in the treatment ofprostate cancer in men as well.[5] The medication was introduced in the U.S. in 1947 bySchering asSynestrol and in France in 1948 asCycladiene.[4] Dienestrol is a closeanalogue ofdiethylstilbestrol.[6] It has approximately 223% and 404% of theaffinity ofestradiol at theERα andERβ, respectively.[7]
Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically.[2]
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