As TCAs have a relatively narrow therapeutic index, the likelihood ofoverdose (both accidental and intentional) is fairly high and should be considered carefully by the prescribing physician prior to patient use. Symptoms of overdose are similar to those of other TCAs, with cardiac toxicity (due to inhibition of sodium and calcium channels) generally occurring before the threshold forserotonin syndrome is reached. Due to this risk, TCAs are rarely selected as the first-line treatment for depression.
Dibenzepin is or was marketed mainly under the brand name Noveril.[3] It has also been marketed under a number of other brand names, including Ansiopax, Deprex, Ecatril, Neodit, and Victoril.[3]
^Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]".Psychiatria Polska (in Polish).25 (3–4):13–8.PMID1687987.
^Gowardman M, Brown RA (March 1976). "Dibenzepin and amitriptyline in depressive states: comparative double-blind trial".The New Zealand Medical Journal.83 (560):194–7.PMID6928.
^Baron DP, Unger HR, Williams HE, Knight RG (April 1976). "A double blind study of the antidepressants dibenzepin (Noveril) and amitriptyline".The New Zealand Medical Journal.83 (562):273–4.PMID8749.
^Roth BL, Driscol J."PDSP Ki Database".Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved14 August 2017.
^abBarth N, Manns M, Muscholl E (1975). "Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart".Naunyn-Schmiedeberg's Arch. Pharmacol.288 (2–3):215–31.doi:10.1007/bf00500528.PMID1161046.S2CID11641400.
^abHyttel J (1978). "Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugs".Biochem. Pharmacol.27 (7):1063–8.doi:10.1016/0006-2952(78)90159-4.PMID656154.
^abcdefghClosse A, Jaton AL (1984). "Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors".Naunyn-Schmiedeberg's Arch. Pharmacol.326 (4):291–3.doi:10.1007/bf00501432.PMID6148707.S2CID24925602.
^abcdefAppl H, Holzammer T, Dove S, Haen E, Strasser A, Seifert R (2012). "Interactions of recombinant human histamine H1R, H2R, H3R, and H4R receptors with 34 antidepressants and antipsychotics".Naunyn-Schmiedeberg's Arch. Pharmacol.385 (2):145–70.doi:10.1007/s00210-011-0704-0.PMID22033803.S2CID14274150.
^abRehavi M, Maayani S, Goldstein L, Assael M, Sokolovsky M (1977). "Antimuscarinic properties of antidepressants: dibenzepin (Noveril)".Psychopharmacology.54 (1):35–8.doi:10.1007/bf00426538.PMID20647.S2CID27031652.
^Rao ML, Frahnert C, Zagorski O (2002). "Initial serotonin transport into viable platelets and imipramine binding to platelet membranes".J Neural Transm (Vienna).109 (5–6):547–56.doi:10.1007/s007020200045.PMID12111448.S2CID9703461.
N
Y (what is this?) (verify)