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Diacetolol

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Chemical compound

Pharmaceutical compound

Diacetolol
Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Eliminationhalf-life	8-13 hours
Identifiers
IUPAC name N-[3-acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
CAS Number	22568-64-5
PubChemCID	50894
ChemSpider	46139^Y
UNII	4ER0CZ5G7C
ChEMBL	ChEMBL2106189
CompTox Dashboard(EPA)	DTXSID70865421
ECHA InfoCard	100.040.974
Chemical and physical data
Formula	C₁₆H₂₄N₂O₄
Molar mass	308.378 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C)C
InChI InChI=1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)^Y Key:AWOGXJOBNAWQSF-UHFFFAOYSA-N^Y
(verify)

Diacetolol is the primarymetabolite ofacebutolol. It is abeta blocker and anti-arrhythmic agent.^[1]

^Basil B, Jordan R (May 1982). "Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol".European Journal of Pharmacology.80 (1):47–56.doi:10.1016/0014-2999(82)90176-5.PMID 6124437.

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan,Bosentan,Macitentan (+tadalafil),Riociguat) selective (Ambrisentan (+tadalafil),Sitaxentan,Sotatercept)