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DiPT

From Wikipedia, the free encyclopedia
Chemical compound
"DIPT" redirects here. For other uses, seeDIPT (disambiguation).
Pharmaceutical compound
DiPT
Clinical data
Trade namesDipt, Dipsy.
Other namesN,N-Diisopropyltryptamine, DiPT
ATC code
  • none
Legal status
Legal status
Identifiers
  • 3-[2-(Diisopropylamino)ethyl]indole
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H24N2
Molar mass244.382 g·mol−1
3D model (JSmol)
  • CC(C)N(CCc1c[nH]c2ccccc12)C(C)C
  • InChI=1S/C16H24N2/c1-12(2)18(13(3)4)10-9-14-11-17-16-8-6-5-7-15(14)16/h5-8,11-13,17H,9-10H2,1-4H3 checkY
  • Key:ZRVAAGAZUWXRIP-UHFFFAOYSA-N checkY
  (verify)

Diisopropyltryptamine (/ˌdˌsˌprpɪlˈtrɪptəmn/; also known asN,N-diisopropyltryptamine orDiPT) is apsychedelichallucinogenic drug of thetryptamine family that has a unique effect. While the majority of hallucinogens affect the visual sense, DiPT is primarilyaural.[1]

Effects

[edit]

DiPT's effects are primarily aural. At lower doses,Alexander Shulgin reported effects similar to aflanging or aphase shift. At medium and higher dosages, the effect of DiPT is typically a radical shift downward in perceivedpitch. This shift tends to benonlinear, in that the shift downwards varies in relation to the initial pitch. This can produce bizarre sounds and render music disharmonious.[1] There has been an experiment involving subjects withperfect pitch, the goal of which was to determine whether the pitch difference is truly distortive or linear, the results of which indicated that there is no clear relationship between perceived pitch and actual pitch.[1] Aside from these, the most prevalent non-auditory effect is inner ear pressure (which has been painful in some instances, for example when combined withMDMA).[1]

Interactions

[edit]
See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Chemistry

[edit]

DiPT is a derivative of tryptamine formed by substitutingisopropyl groups for the two hydrogen atoms attached to the non-aromatic nitrogen atom in the tryptamine molecule.

Pharmacodynamics

[edit]
Binding sitesBinding affinity (Ki, μM)[2]
5-HT1A0.538
5-HT2A1.2
5-HT2C6.5
D1>25
D2>25
D3>25
α1A>12
α2A3.6
TAAR1>15
H10.92
SERT0.18
DAT4.1
NET8.9

Legal status

[edit]

United Kingdom

[edit]

As is the case with many psychedelic tryptamines and phenethylamines, it isClass A in the UK, making it illegal to possess or use.

United States

[edit]

DiPT is notscheduled at the federal level in theUnited States,[3] but it could be considered an analog of5-MeO-DiPT, in which case purchase, sale, or possession for human consumption or illicit use that is not for scientific or industrial purposes could be prosecuted under theFederal Analog Act. Some of the people arrested inOperation Web Tryp were selling DiPT, however the drug is not explicitly forbidden or outlawed.

However the US Drug Enforcement Agency (DEA) withdrew a proposal to ban five psychedelic substances including 4-Hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), N-Isopropyl-5-Methoxy-N-Methyltryptamine (5-MeO-MiPT) and N,N-Diisopropyltryptamine (DiPT). DEA withdrew the proposed listing as schedule 1 banned substance after a public hearing in 2022.[4]

Florida

[edit]

"DiPT (N,N-Diisopropyltryptamine)" is a Schedule Icontrolled substance in the state ofFlorida making it illegal to buy, sell, or possess in Florida.[5]

Sweden

[edit]

Sweden's public health agency suggested classifying DiPT as ahazardous substance, on May 15, 2019.[6]

See also

[edit]

References

[edit]
  1. ^abcdShulgin A (1997).TiHKAL: Tryptamines I Have Known and Loved. Berkeley, CA USA: Transform Press. pp. 403–406.ISBN 0-9630096-9-9.
  2. ^Rickli A, Moning OD, Hoener MC, Liechti ME (August 2016)."Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens"(PDF).European Neuropsychopharmacology.26 (8):1327–37.doi:10.1016/j.euroneuro.2016.05.001.PMID 27216487.S2CID 6685927.
  3. ^"21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I."Drug Enforcement Administration (DEA). U.S. Department Of Justice. Archived fromthe original on 2009-08-27. Retrieved2014-12-17.
  4. ^"Placement of 4-hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT), 5-methoxy-N,N-diethyltryptamine (5-MeO-DET), and N,N-diisopropyltryptamine (DiPT) in Schedule I; Withdrawal of Proposed Rule". 27 July 2022.
  5. ^"Chapter 893 - Drug Abuse Prevention and Control".Florida Statutes.
  6. ^"Folkhälsomyndigheten föreslår att 20 ämnen klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 15 May 2019. Archived fromthe original on 20 October 2021. Retrieved11 November 2019.

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