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Dexbrompheniramine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Dexbrompheniramine
Clinical data
Trade namesDrixoril, Conex, Dixaphedrine
AHFS/Drugs.comMultum Consumer Information
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Eliminationhalf-life25 hours
Identifiers
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.004.595Edit this at Wikidata
Chemical and physical data
FormulaC16H19BrN2
Molar mass319.246 g·mol−1
3D model (JSmol)
  • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
  • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dexbrompheniramine is anantihistamine withanticholinergic properties[1] used to treatallergic conditions such ashay fever orurticaria. It is the pharmacologically active dextrorotatory isomer ofbrompheniramine. It was formerly marketed in combination withpseudoephedrine under the nameDrixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine is a first generation antihistamine that reduces the effects of theneurotransmitterhistamine in the body; sneezing, itching, watery eyes, and runny nose.

Interactions

[edit]

MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Drinking alcohol can increase side effects of dexbrompheniramine.

References

[edit]
  1. ^Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis".The Journal of International Medical Research.6 (1):56–60.doi:10.1177/030006057800600110.PMID 627306.S2CID 39205584.

External links

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