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| Clinical data | |
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| Trade names | Deramaxx |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Protein binding | High (more than 90%) |
| Metabolism | Hepatic biotransformation |
| Eliminationhalf-life | 3 hours at 2–3 mg/kg |
| Excretion | In feces |
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| CAS Number | |
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| UNII | |
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| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.234.875 |
| Chemical and physical data | |
| Formula | C17H14F3N3O3S |
| Molar mass | 397.37 g·mol−1 |
| 3D model (JSmol) | |
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Deracoxib (trade nameDeramaxx) is anonsteroidal anti-inflammatory drug (NSAID) of thecoxib class, used in dogs to treat pain associated withosteoarthritis, or to prevent pain following orthopedic or dental surgery. It is available as beef-flavored tablets.[1]
Deracoxib is used in dogs for the control of pain and inflammation associated with osteoarthritis and for the prevention of pain following orthopedic surgery or dental procedures.[2]
In cats, the use of deracoxib is not recommended.[3]
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Deracoxib is contraindicated for treatment of dogs with hypersensitivity to deracoxib or otherNSAIDs, and dogs with gastro-intestinal ulcers, renal disease, hepatic disorders, hypoproteinemia, dehydration, or cardiac disease.
Dogs with renal disease may need dose adjustment (if the benefits of the medication outweigh the risks), while those on concurrent diuretic therapy are at increased risk for NSAID toxicity and should not be given this medication.
The concurrent use of deracoxib with steroids or other NSAIDs should be avoided. The safety of deracoxib has not been established in pregnant or nursing dogs or in dogs younger than 4 months of age.
The most common adverse effects of treatment with deracoxib are vomiting, anorexia, lethargy and depression.[4] Other adverse effects of deracoxib are caused by its effects on thegastrointestinal tract, and include erosions or ulcerations of the lining of the stomach or intestines.[5]
Serious adverse effects, including ulcers which perforate the gastrointestinal tract, have occurred in dogs administered higher than recommended doses of deracoxib, or dogs administered deracoxib at the same time as (or soon after) otherNSAIDs orcorticosteroid medications.[4]
Documented adverse side effects include serious and sometimes fatal organ system damage or failure.[6] Other side effects include increase in drinking or urination, jaundice, bloody or black stools, pale gums, hot spots, increased respiration (fast or heavy breathing), incoordination, and behavior changes.[citation needed]
Deracoxib is a coxib classnonsteroidal anti-inflammatory drug (NSAID).[3] Like other NSAIDs, its effects are caused by inhibition ofcyclooxygenase (COX) enzymes.[7] At the doses used to treat dogs, deracoxib causes greater inhibition ofCOX-2 than ofCOX-1,[3] but at doses twice those recommended for use in dogs, deracoxib significantly inhibitsCOX-1 as well.[8]
In dogs, thehalf-life of deracoxib at the recommended dose is three hours.[8]
In the U.S., deracoxib was first approved for use in dogs in 2002, under the trade name Deramaxx chewable tablets, sold byNovartis Animal Health.[1]
| pyrazolones / pyrazolidines | |
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| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
