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| Names | |
|---|---|
| IUPAC names (3S)-3-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-3-phenylpropanamido]-3-{[(1S)-1-{[(1S)-1-[(carbamoylmethyl)carbamoyl]-2-methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}propanoic acid or L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-valylglycinamide | |
| Other names [D-Ala2]Deltorphin I; Deltorphin C | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
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| Properties | |
| C37H52N8O10 | |
| Molar mass | 768.856 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Deltorphin I, also known as[D-Ala2]deltorphin I ordeltorphin C, is anaturally occurring,exogenousopioidheptapeptide and hence,exorphin, with theamino acid sequence Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2.[1][2] While not known to beendogenous to humans or other mammals, deltorphin I, along with the otherdeltorphins and thedermorphins, is produced naturally in the skin of species ofPhyllomedusa,[1] a genus offrogs native toSouth andCentral America. Deltorphin possesses very highaffinity andselectivity as anagonist for theδ-opioid receptor,[1][2] and on account of its unusually highblood-brain-barrier penetration rate,[3] producescentrally-mediatedanalgesic effects in animals even when administeredperipherally.[4]
