Cascarino started playing football for her local youth teams of A.S. St. Priest and A.S. A.S. Manissieux St Priest before joiningLyon in 2009.[1] She made her senior debut for Lyon in theDivision 1 Féminine in the2014–15 season.[2][3] She was rewarded with her first professional contract in 2015.[2] In January 2017, her season was ended early due to a knee injury.[4] By 2018, she had won threeUEFA Women's Champions League and three Division 1 titles with Olympic Lyonnais.[5] On 7 May 2021, Cascarino extended her contract with Lyon through the club's 2023–24 season.[6]
On 25 May 2023, Lyon announced that Cascarino would be sidelined for several months after rupturing an anterior cruciate ligament.[7] She made her return to the field in January 2024 and later scored three goals across two UWCL quarterfinal matches as Lyon progressed to the final.[8]
On 24 July 2024, Cascarino joinedNational Women's Soccer League clubSan Diego Wave FC, signing a three-year contract with an additional option.[9] She made her NWSL debut on 24 August, appearing as a substitute in a defeat toAngel City FC.[10] On 15 September, Cascarino tallied her first goal and first assist with San Diego in a 2–1 victory over theUtah Royals.[11]
Cascarino started the following season on a positive note, tallying an assist in the Wave's opening match and subsequently being a nominee for theNWSL Player of the Week.[12] Despite not winning the opening week accolade, she later received her first Player of the Week award after recording an assist and notching her first NWSL brace in a 4–1 win overRacing Louisville FC a month later.[13][14] At the end of April, Cascarino was named to theNWSL Team of the Month for the first time.[15] She continued to be productive offensively in May, including during a 5–2 victory over theNorth Carolina Courage. Cascarino, who recorded an assist, helped contribute to the win, which set a club record for goals scored in a single match and extended San Diego's unbeaten streak to six games.[16] Five months later, the Wave increased its single-game scoring record after putting 6 pastChicago Stars FC in the penultimate match of San Diego's 2025 season. Cascarino scored the opening goal in the 6–1 win as the Wave also clinched a spot in the playoffs with the victory.[17]
In 2012, Cascarino was selected to play for the France women's national under-17 football team, where she was part of their2012 FIFA U-17 Women's World Cup winning campaign.[18] During the tournament, she played in all three of France's group stage games and recorded three assists in the team's match againstGambia.[19] Cascarino also appeared in each of France's knockout matches and took successful spot-kicks in two penalty shootouts on the squad's road to victory.[20] HercaptainSandie Toletti said of Cascarino: "It's a great discovery, knowing that she was not part of the last European championship. She is already a great player, despite her young age."[21]
In 2016, Cascarino made her senior debut for France againstEngland.[22] She scored her first goal with the senior team on 10 November 2018, in a 3–1 win againstBrazil.[23] The following year, Cascarino was named to the French squad for the2019 FIFA Women's World Cup.[24] The team made it to the quarterfinals of the tournament before being eliminated by the United States.[25]
Cascarino is the twin sister ofEstelle Cascarino, also a football player, who played alongside her sister at Lyon before moving toParis FC in 2016.[29] They are not related toTony Cascarino, although they are often asked if they are:[30] "I am often asked if I am from his family, that is not the case ... I know that he notably played forNancy and that he is Irish. Me, I'm not Irish at all! (laughs)"[31] Her father is Italian and her mother comes fromGuadeloupe.[32]