Decoy receptor 3 (Dcr3), also known astumor necrosis factor receptor superfamily member 6B (TNFRSF6B),TR6 andM68, is a soluble protein of thetumor necrosis factor receptor superfamily which inhibitsFas ligand-inducedapoptosis.[3][4][5]
Theopen reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[5] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
This gene belongs to thetumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes withdeath receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressingFasL- and LIGHT-mediated cell death and T cell activation as well as to induceangiogenesis via neutralization ofTL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.[5]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^abPitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer".Nature.396 (6712):699–703.doi:10.1038/25387.PMID9872321.S2CID4427455.
Mild G, Bachmann F, Boulay JL, et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer".Int. J. Cancer.102 (3):254–7.doi:10.1002/ijc.10711.PMID12397645.S2CID23680078.
Hsu MJ, Lin WW, Tsao WC, et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3".Exp. Cell Res.292 (2):241–51.doi:10.1016/j.yexcr.2003.09.019.PMID14697332.
