Strathairn is acharacter actor, appearing in supporting roles in many independent and Hollywood films. In this capacity, he has co-starred inTwisted as a psychiatrist; inThe River Wild as a husband; and inBlue Car as a teacher. Other notable film roles include his portrayals of baseball playerEddie Cicotte inEight Men Out (1988); Col. Craig Harrington inMemphis Belle (1990); Whistler, the wisecracking blind techie, inSneakers (1992); convict Ray McDeere in the legal thrillerThe Firm (1993); abusive husband Joe St. George inDolores Claiborne (1995); Pierce Patchett, a millionaire involved in the seedy side of 1950s Los Angeles inL.A. Confidential (1997);Theseus, Duke of Athens, in the1999 version ofA Midsummer Night's Dream; and the title character inHarrison's Flowers (2000)
Strathairn's television work also includes a wide range of roles: Moss, the bookselling nebbish on the critically acclaimedThe Days and Nights of Molly Dodd; Captain Keller, the father ofHelen Keller in the 2000 remake ofThe Miracle Worker;Capt. Frederick Benteen, a U.S. 7th Cavalry officer underGeneral Custer's command inSon of the Morning Star; and a far-out (both figuratively and literally) televangelist inParadise, the pilot episode for a TV series onShowtime that was not successful. Strathairn had a recurring role on the hit television dramaThe Sopranos. Strathairn starred in theMiami Vice episode "Out Where the Buses Don't Run."
Strathairn appeared inWe Are Marshall, a 2006 film about the rebirth ofMarshall University's football program after the 1970 plane crash that killed most of the team's members; andCold Souls, starringPaul Giamatti as a fictionalized version of himself, who enlists a company's services to deep freeze his soul, directed bySophie Barthes. In 2006 he did a campaign ad for then congressional candidate (now Senator)Kirsten Gillibrand. He reprised his role as Edward R. Murrow in a speech similar to the one fromGood Night, and Good Luck, but was altered to reference Gillibrand's opponent John Sweeney.[12]
Strathairn plays the lead role in the 2007 independent film,Steel Toes, a film byDavid Gow (writer/co-director/producer) and Mark Adam (co-director/DOP/editor). The film is based on Gow's stage playCherry Docs, in which Strathairn starred for its American premiere at theWilma Theatre in Philadelphia.
He played a role inParamount Pictures' children's filmThe Spiderwick Chronicles (2008) as Arthur Spiderwick. Strathairn appeared in theAmerican Experience PBS anthology series documentary,The Trials of J. Robert Oppenheimer, a biography of the physicist. He first played Oppenheimer in the 1989 CBS TV movieDay One.
He played William Flynn, an FBI agent dealing with anarchism in 1920s New York City, inNo God, No Master. He starred as Dr. Lee Rosen onSyfy's seriesAlphas.[14]
In 2018–19, Strathairn appeared on the third and fourth seasons of SyFy'sThe Expanse[15][16] as Klaes Ashford.
In 2020, Strathairn was one of the few professional actors in the Oscar-winnerNomadland, directed byChloé Zhao. He appears alongside his son Tay, the first time they have acted together on screen since 1988'sEight Men Out when Tay was just eight years old.
Strathairn starred in the 2023 filmRemember This, based on the stage play about the life of Polish diplomat and war heroJan Karski who brought evidence of the Holocaust to Western governments during WW2. The film is executive-produced by Eva Anisko and directed by Jeff Hutchens and Derek Goldman.
Strathairn playedJan Karski in the one-man playRemember This: The Lesson of Jan Karski, written by Clark Young and Derek Goldman. The play is an original production by The Laboratory for Global Performance and Politics at Georgetown University. In 2021, Strathairn garnered critical acclaim for a production ofRemember This at theChicago Shakespeare Theater.[26]
^Performance revs. by Susan Hollis Merritt, "The Birthday Party" (CSC Repertory Theatre, New York, April 17, 1988, April 12, 1988 – May 22, 1988) and Bernard Dukore, "The Birthday Party" (CSC Repertory Theatre, New York, April–May 1988),The Pinter Review 2.1 (1988): 66–70; 71–73. (Cover photograph features Strathairn in his role as Stanley.)
^Susan Hollis Merritt, "A Conversation withCarey Perloff, Bill Moor,Peter Riegert,Jean Stapleton, and David Strathairn: After Matinee ofMountain Language andThe Birthday Party byCSC Repertory Ltd., Bruno's, New York, Nov. 12, 1989",The Pinter Review: Annual Essays 1989 (TPR) (Tampa: U of Tampa P, 1989) 59–84 (interview); cf. performance rev. by Francis Gillen, "Mountain Language,The Birthday Party"TPR 93–97. (Cover photograph features Strathairn and Stapleton in their roles as a prison Officer and the Elderly Woman inMountain Language; his other role, the Prisoner, is the Elderly Woman's son.)
^Performance revs. by Katherine H. Burkman, "Ashes to Ashes in New York:Roundabout Theatre Company at the Gramercy Theatre, March 30, 1999" and by Susan Hollis Merritt, "Ashes to Ashes in New York: Roundabout Theatre Company, Gramercy Theatre, New York, April 3, 1999",The Pinter Review: Collected Essays 1997 and 1998 (Tampa: U of Tampa P, 1999) 154-59.