David Ho | |||||||||||||||||
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| 何大一 | |||||||||||||||||
.jpg) Ho in 2012 | |||||||||||||||||
| Born | (1952-11-03)November 3, 1952 (age 72) | ||||||||||||||||
| Education | California Institute of Technology (BS) Harvard University (MD) | ||||||||||||||||
| Known for | HIV/AIDS research | ||||||||||||||||
| Awards | Ernst Jung Prize (1991) Bristol-Myers Squibb Award (1996) American Academy of Arts and Sciences (1997) Presidential Citizens Medal (2001) | ||||||||||||||||
| Scientific career | |||||||||||||||||
| Fields | Virology | ||||||||||||||||
| Institutions | Columbia University Rockefeller University | ||||||||||||||||
| Chinese name | |||||||||||||||||
| Chinese | 何大一 | ||||||||||||||||
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| Website | www | ||||||||||||||||
David Da-i Ho (Chinese:何大一;pinyin:Hé Dà-yī; born November 3, 1952) is aTaiwanese-American[1][2][3][4][5]AIDS researcher, physician, andvirologist who has made a number of scientific contributions to the understanding andtreatment of HIV infection.[6] He was a pioneer ofcombination anti-retroviral therapy instead ofsingle therapy,[7][8] which turnedHIV from an absoluteterminal disease into achronic disease.[9]
Ho was born in Taiwan in 1952 and immigrated to the United States in 1965.[10] After graduating from theCalifornia Institute of Technology, he earned hisDoctor of Medicine (M.D.) fromHarvard Medical School before receiving his clinical training at theUCLA School of Medicine andMassachusetts General Hospital.
He is the founding scientific director of theAaron Diamond AIDS Research Center[11] and the Clyde and Helen Wu Professor of Medicine atColumbia University Vagelos College of Physicians and Surgeons,[12] both housed atColumbia University Irving Medical Center.[12][13]
David Ho was born inTaichung,Taiwan, to Paul (何步基;Hé Bùjī), an engineer, and Sonia Ho (née Jiang) (江雙如;Jiāng Shuāngrú). He attended Taichung Municipal Guang-Fu Elementary School until sixth grade beforeimmigrating to theUnited States with his mother and younger brother to unite with his father, who had already been in the US since 1957.[10]
Ho grew up inLos Angeles and graduated fromJohn Marshall High School. He received hisBachelor of Science inbiology with highest honors from theCalifornia Institute of Technology (1974).[14] In 1978, Ho earned aDoctor of Medicine (M.D.) fromHarvard Medical School.
Ho has been engaged inHIV/AIDS research since the beginning of thepandemic, initially focusing on clinicalvirology and select topics in HIV pathogenesis, includingHIV drug resistance. Before1996,AZT[8] and other early 1990santiretroviral medication were prescribed insingle therapy, which still did not preventprogression to fatal full-blown AIDS.[8][15] In the mid-1990s, his research team conducted a series of elegant human studies to elucidate the dynamics of HIV replication in vivo.[16] This knowledge, in turn, formed the foundation for their pioneering effort to treat HIV "early andhard"[8] and in demonstrating for the first time the durable control of HIV replication in patients receivingcombination antiretroviral therapy,[17][18] which had been subsequently developed by scientists atNIAID andMerck.[19] He and hisADARC team presented the remarkable results from using combination antiretroviral therapy atInternational AIDS Conference 1996.[20] This was the turning point in the epidemic that an automatic death sentence was transformed into amanageable disease.[21][16]
Ho has published more than 500 research papers as of February 2020.[22]
Ho is a member of theCommittee of 100, aChinese American leadership organization, in addition to several scientific groups.[16]
Ho led a team, funded by theJack MaFoundation, to look for a vaccine for theCOVID-19 virus.[23]
Ho wasTime magazine's 1996Man of the Year.Time later recalled the selection surprising both Ho and readers.[24][25][26] The magazine acknowledged in 1996 that "Ho is not, to be sure, a household name. But some people make headlines while others make history."[24] As of 2024, Ho is the last person to be selected as Person of the Year in a U.S. presidential election year without winning that year's U.S. presidential election. In 1998, he received the Golden Plate Award of theAmerican Academy of Achievement.[27][28] Ho was even briefly mentioned whenAlexander Fleming was considered for Person of the Century in 1999, since Fleming could be portrayed as representative of other disease-fighting scientists including Ho,[29] but the title ultimately went toAlbert Einstein.
Ho was the chosen commencement speaker atCaltech,[30]MIT,[31] andHarvard T. H. Chan School of Public Health in 2000.
Ho has received numerous honors and awards for his scientific accomplishments. On January 8, 2001, he was presented with thePresidential Citizens Medal by PresidentClinton.[32][33]
On December 6, 2006,California governorArnold Schwarzenegger and First LadyMaria Shriver inducted Ho into theCalifornia Hall of Fame located atThe California Museum for History, Women, and the Arts.[34]
Ho was awarded the Distinguished Alumni Award byCalifornia Institute of Technology in 2015.[35] Ho received the Portrait of a Nation Prize at the National Portrait Gallery, Smithsonian Institution in 2017.[36]
Other accolades include theErnst Jung Prize in Medicine,[37]Mayor's Award for Excellence in Science & Technology, the Squibb Award,[38] the Architect of Peace[39] and the Hoechst Marion Roussel Award.[40]
Ho has been elected as a member of theAmerican Academy of Arts and Sciences,Academia Sinica (Taiwan), and the U.S.National Academy of Medicine (formerly Institute of Medicine).[16] He is currently a member of the board of trustees of theCalifornia Institute of Technology.[41] He was a member of the Board of Overseers ofHarvard University and a board member of theMIT Corporation.[42][16]
He is also a member of theChinese Academy of Engineering.[16]
Ho was recognized by the Kingdom of Thailand with thePrince Mahidol Award in Medicine.[43]
Ho was awarded Hamdan Award for Medical Research Excellence - Immunity in 2022.[44]
Ho's family's ancestral home isXinyu,Jiangxi Province.[45] He is married to Tera Wong, with whom he has four children: Kathryn, Jonathan, Jaclyn, and Jerren.[46]
David Ho, MD, for pioneering treatment of HIV/AIDS. Dr. Ho is a Taiwanese American physician who was namedTime'sMan of the Year in 1996
... zidovudine was shown in 1990 to slow the clinical progression to AIDS in infected but asymptomatic subjects. However, a follow-up of those subjects found no evidence of longer survival with the use ofzidovudine...
...joined Columbia University Irving Medical Center on January 1, 2020. Dr. David Ho remains as the Center's Director and has been named the Clyde and Helen Wu Professor of Medicine at Columbia University.
... it's inevitable for HIV to develop drug resistance if you give it one drug at a time...
... We came to the conclusion that it's inevitable for HIV to develop drug resistance if you give it one drug at a time...
... if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult or statistically improbable for HIV to become resistant to all the drugs simultaneously.
... However, if you start to combine the drugs and try to force the virus into a corner using multiple drugs, it is exceedingly difficult...for HIV to become resistant to all the drugs simultaneously.
International AIDS Conference 1996 in Vancouver showing combination therapy results
... response with combination therapy was rather dramatic...we see some deathly ill patients totally recover after two to three weeks of good therapy...people got out of their deathbed after a few weeks of therapy.
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