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Datumetine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Datumetine
Molecule of datumetine
Identifiers
  • 4-Methoxy-3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)benzoic acid
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H21NO3
Molar mass275.348 g·mol−1
3D model (JSmol)
  • O=C(O)C1=CC=C(OC)C(=C1)C2CC3N(C)C(CC3)C2
  • InChI=1S/C16H21NO3/c1-17-12-4-5-13(17)8-11(7-12)14-9-10(16(18)19)3-6-15(14)20-2/h3,6,9,11-13H,4-5,7-8H2,1-2H3,(H,18,19)
  • Key:CMMJWJKGQZIJPB-UHFFFAOYSA-N

Datumetine is atropane alkaloid found in leaves ofDatura metel.[1] It is said tomodulateNMDA receptor and thus causes memory loss.[2] It also causes epileptic seizures in mice.[2]Docking studies suggest that it fits on bothallosteric andorthosteric sites of NMDA receptor.[2] It acts together with otheranticholinergic tropane alkaloids of datura to cause amnesia.[citation needed]

See also

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References

[edit]
  1. ^Siddiqui S, Sultana N, Ahmed SS, Haider SI (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves ofDatura metel".Journal of Natural Products.49 (3):511–513.doi:10.1021/np50045a023.ISSN 0163-3864.
  2. ^abcIshola AO, Imam A, Ajao MS (2021)."Effects of datumetine on hippocampal NMDAR activity".Toxicology Reports.8:1131–1142.doi:10.1016/j.toxrep.2021.05.009.PMC 8190477.PMID 34150523.
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