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DYNLT3

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
DYNLT3
Identifiers
AliasesDYNLT3, RP3, TCTE1L, TCTEX1L, dynein light chain Tctex-type 3
External IDsOMIM:300302;MGI:1914367;HomoloGene:21304;GeneCards:DYNLT3;OMA:DYNLT3 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for DYNLT3
Genomic location for DYNLT3
BandXp11.4Start37,836,757bp[1]
End37,847,571bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for DYNLT3
Genomic location for DYNLT3
BandX|X A1.1Start9,520,506bp[2]
End9,529,242bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gums

  • gingival epithelium

  • Pons

  • dorsal motor nucleus of vagus nerve

  • pars compacta

  • Brodmann area 23

  • lateral nuclear group of thalamus

  • optic nerve

  • oral cavity

  • glomerulus
Top expressed in
  • Epithelium of choroid plexus

  • transitional epithelium of urinary bladder

  • seminal vesicula

  • deep cerebellar nuclei

  • medial vestibular nucleus

  • retinal pigment epithelium

  • lateral geniculate nucleus

  • epithelium of lens

  • conjunctival fornix

  • facial motor nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6990

67117

Ensembl

ENSG00000165169

ENSMUSG00000031176

UniProt

P51808

P56387

RefSeq (mRNA)

NM_006520

NM_025975

RefSeq (protein)

NP_006511

NP_080251

Location (UCSC)Chr X: 37.84 – 37.85 MbChr X: 9.52 – 9.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynein, light chain, Tctex-type 3, also known asDYNLT3, is aprotein which in humans is encoded by theDYNLT3gene.[5][6]

Function

[edit]

DYNLT3 is a member of thedynein motor protein family. DYNLT3 binds toBUB3, aspindle checkpoint protein is present onkinetochores atprometaphase.[7] DYNLT3 can also function as a transcription regulator ofBcl-2 gene through binding toSATB1 in a dynein-independent manner.[8]

Interactions

[edit]

DYNLT3 has been shown tointeract withVDAC1.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000165169Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000031176Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3".
  6. ^Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex".Hum. Mol. Genet.3 (2):257–63.doi:10.1093/hmg/3.2.257.PMID 8004092.
  7. ^Lo KW, Kogoy JM, Pfister KK (April 2007)."The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3".J. Biol. Chem.282 (15):11205–12.doi:10.1074/jbc.M611279200.PMID 17289665.
  8. ^Yeh TY, Chuang JZ, Sung CH (August 2005)."Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway".J. Cell Sci.118 (Pt 15):3431–43.doi:10.1242/jcs.02472.PMID 16079286.
  9. ^Schwarzer, Christian; Barnikol-Watanabe Shitsu; Thinnes Friedrich P; Hilschmann Norbert (Sep 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74".Int. J. Biochem. Cell Biol.34 (9):1059–70.doi:10.1016/S1357-2725(02)00026-2.ISSN 1357-2725.PMID 12009301.S2CID 11632830.

Further reading

[edit]


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