| Dedicator of cytokinesis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Ded_cyto | ||||||||||
| Pfam | PF06920 | ||||||||||
| InterPro | IPR026791 | ||||||||||
| SCOP2 | 1wg7 /SCOPe /SUPFAM | ||||||||||
| CDD | cd11684 | ||||||||||
| |||||||||||
DOCK (Dedicatorofcytokinesis) is a family of relatedproteins involved inintracellularsignalling networks.[1] DOCK family members contain aRhoGEF domain to function asguanine nucleotide exchange factors to promoteGDP release andGTP binding to specificSmall GTPases of theRho family (e.g.,Rac andCdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.
DOCK family proteins are categorised into four subfamilies based on theirsequence homology:
