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DNM3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

DNM3

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3L43,5A3F

Identifiers

Aliases

DNM3, Dyna III, dynamin 3

External IDs

OMIM:611445;MGI:1341299;HomoloGene:22906;GeneCards:DNM3;OMA:DNM3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q24.3	Start	171,817,887bp^[1]
Band	1q24.3	End	172,418,466bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 H2.1	Start	161,810,022bp^[2]
Band	1\|1 H2.1	End	162,305,603bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lateral nuclear group of thalamus

pons

Brodmann area 46

corpus callosum

pars compacta

postcentral gyrus

superior vestibular nucleus

dorsal motor nucleus of vagus nerve

pars reticulata

orbitofrontal cortex

Top expressed in

facial motor nucleus

anterior horn of spinal cord

superior colliculus

central gray substance of midbrain

inferior colliculi

pontine nuclei

medial vestibular nucleus

substantia nigra

dorsal tegmental nucleus

nucleus of stria terminalis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding nitric-oxide synthase binding type 1 metabotropic glutamate receptor binding GTP binding type 5 metabotropic glutamate receptor binding protein binding hydrolase activity GTPase activity microtubule binding identical protein binding structural constituent of postsynapse
Cellular component	cytoplasm Golgi apparatus postsynaptic density photoreceptor inner segment dendritic spine synapse axon dendritic spine head mitochondrion perinuclear region of cytoplasm synaptic cleft microtubule extracellular exosome cytoskeleton mitochondrial membranes postsynaptic endocytic zone membrane plasma membrane membrane cytoplasmic vesicle postsynaptic membrane apical tubulobulbar complex basal tubulobulbar complex presynapse glutamatergic synapse
Biological process	endocytosis positive regulation of filopodium assembly regulation of dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission synapse assembly filopodium assembly membrane fusion synaptic vesicle budding from presynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization receptor internalization synaptic vesicle endocytosis regulation of synapse structure or activity postsynapse organization positive regulation of synaptic vesicle recycling
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


26052


103967

Ensembl


ENSG00000197959


ENSMUSG00000040265

UniProt


Q9UQ16


Q8BZ98

RefSeq (mRNA)

NM_001136127 NM_001278252 NM_015569 NM_001350204 NM_001350205
NM_001350206


NM_001038619 NM_172646

RefSeq (protein)

NP_001129599 NP_001265181 NP_056384 NP_001337133 NP_001337134
NP_001337135


NP_001033708 NP_766234

Location (UCSC)

Chr 1: 171.82 – 172.42 Mb

Chr 1: 161.81 – 162.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dynamin-3 is aprotein that in humans is encoded by theDNM3gene.^[5]^[6] Theprotein encoded by this gene is a member of thedynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.^[7] DNM3 is upregulated inSézary's syndrome.^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000197959 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000040265 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999)."Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.5 (6):355–64.doi:10.1093/dnares/5.6.355.PMID 10048485.
^"Entrez Gene: DNM3 dynamin 3".
^Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface".Curr. Opin. Cell Biol.15 (1):31–9.doi:10.1016/S0955-0674(02)00010-8.PMID 12517701.
^Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008)."Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3".Leukemia.22 (2):393–9.doi:10.1038/sj.leu.2405044.PMID 18033314.

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:Q9UQ16 (Dynamin-3) at thePDBe-KB.

Membrane protein:vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18:STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP:VAMP1 VAMP2 VAMP3

Synaptotagmin

Other

Small GTPase:RAB3A

COPI

Coatomer

Small GTPase:ARF

COPII

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase:SAR1A

RME/Clathrin

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47