Protein-coding gene in humans
Death effector domain containing protein is aprotein that in humans is encoded by theDEDD gene .[ 5] [ 6] [ 7]
This gene encodes a protein that contains a death effectordomain (DED). DED is aprotein–protein interaction domain shared by adaptors, regulators and executors of theprogrammed cell death pathway.Overexpression of this gene was shown to induce weakapoptosis . Upon stimulation, this protein was found totranslocate from cytoplasm to nucleus and colocalize withUBTF , a basal factor required forRNA polymerase I transcription, in thenucleolus . At least three transcript variants encoding the same protein have been found for this gene.[ 7]
DEDD has been shown tointeract with:
^a b c GRCh38: Ensembl release 89: ENSG00000158796 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000013973 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^a b Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998)."DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" .EMBO J .17 (20):5974– 86.doi :10.1093/emboj/17.20.5974 .PMC 1170924 PMID 9774341 . ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998)."DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells" .Endocrinology .139 (12):4839– 48.doi :10.1210/endo.139.12.6335 PMID 9832420 . ^a b "Entrez Gene: DEDD death effector domain containing" .^a b Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (Apr 2002)."Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" .Cell Death Differ .9 (4):439– 47.doi :10.1038/sj.cdd.4401038 PMID 11965497 . ^a b Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (Mar 2002)."Identification and characterization of DEDD2, a death effector domain-containing protein" .J. Biol. Chem .277 (9):7501– 8.doi :10.1074/jbc.M110749200 PMID 11741985 . ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Oct 1998)."DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" .EMBO J .17 (20):5974– 86.doi :10.1093/emboj/17.20.5974 .PMC 1170924 PMID 9774341 . ^ Alcivar A, Hu S, Tang J, Yang X (Jan 2003)."DEDD and DEDD2 associate with caspase-8/10 and signal cell death" .Oncogene .22 (2):291– 7.doi :10.1038/sj.onc.1206099 PMID 12527898 .
Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E (2005)."Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation" .Int. J. Cancer .115 (3):412– 8.doi :10.1002/ijc.20857 PMID 15688372 . Alcivar A, Hu S, Tang J, Yang X (2003)."DEDD and DEDD2 associate with caspase-8/10 and signal cell death" .Oncogene .22 (2):291– 7.doi :10.1038/sj.onc.1206099 PMID 12527898 . Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME (2002)."DEDD regulates degradation of intermediate filaments during apoptosis" .J. Cell Biol .158 (6):1051– 66.doi :10.1083/jcb.200112124 .PMC 2173221 PMID 12235123 . Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2002)."Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" .Cell Death Differ .9 (4):439– 47.doi :10.1038/sj.cdd.4401038 PMID 11965497 . Schickling O, Stegh AH, Byrd J, Peter ME (2002)."Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription" .Cell Death Differ .8 (12):1157– 68.doi :10.1038/sj.cdd.4400928 PMID 11753564 . Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (2002)."Identification and characterization of DEDD2, a death effector domain-containing protein" .J. Biol. Chem .277 (9):7501– 8.doi :10.1074/jbc.M110749200 PMID 11741985 .
