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DCLK1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

DCLK1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1MFW,1MG4,1UF0

Identifiers
AliasesDCLK1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDsOMIM:604742;MGI:1330861;HomoloGene:130530;GeneCards:DCLK1;OMA:DCLK1 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for DCLK1
Genomic location for DCLK1
Band13q13.3Start35,768,652bp[1]
End36,131,382bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for DCLK1
Genomic location for DCLK1
Band3|3 CStart55,149,785bp[2]
End55,446,489bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • frontal pole

  • Brodmann area 10

  • Brodmann area 23

  • pars reticulata

  • pars compacta

  • Occipital Lobe

  • middle temporal gyrus

  • superior vestibular nucleus

  • primary visual cortex
Top expressed in
  • stria vascularis

  • Rostral migratory stream

  • piriform cortex

  • vestibular sensory epithelium

  • habenula

  • visual cortex

  • superior frontal gyrus

  • primary visual cortex

  • primary motor cortex

  • prefrontal cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9201

13175

Ensembl

ENSG00000133083

ENSMUSG00000027797

UniProt

O15075

Q9JLM8

RefSeq (mRNA)
NM_001195415
NM_001195416
NM_001195430
NM_004734
NM_001330071

NM_001330072

NM_001111051
NM_001111052
NM_001111053
NM_001195538
NM_001195539

NM_001195540
NM_019978
NM_001357466
NM_001357468
NM_001357469
NM_001357475
NM_001357476

RefSeq (protein)
NP_001182344
NP_001182345
NP_001182359
NP_001317000
NP_001317001

NP_004725

NP_001104521
NP_001104522
NP_001104523
NP_001182467
NP_001182468

NP_001182469
NP_064362
NP_001344395
NP_001344397
NP_001344398
NP_001344404
NP_001344405

Location (UCSC)Chr 13: 35.77 – 36.13 MbChr 3: 55.15 – 55.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Doublecortin-like kinase protein 1 (DCLK1)[5][6][7][8] is anenzyme that in humans is encoded by theDCLK1gene.[5][6][8] Its C-terminal domain in rats is expressed independently from an alternative transcript,cpg16, and can function alone as aserine/threonine protein kinase that iscyclic AMP dependent.[9][10]

DCLK1 expression is a marker fortuft cells, a type of chemosensory cell of the intestinal epithelium.[7][11]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000133083 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000027797 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abOmori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998)."Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin".J Hum Genet.43 (3):169–77.doi:10.1007/s100380050063.PMID 9747029.
  6. ^abSossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)".Genomics.56 (1):121–6.doi:10.1006/geno.1998.5718.PMID 10036192.
  7. ^abDing L, Weygant N, Ding C, Lai Y, Li H (2023). "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy".Critical Reviews in Oncology and Hematology.191.doi:10.1016/j.critrevonc.2023.104118.PMID 37660932. Art. No. 104118.
  8. ^ab"Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1".Gene. National Library of Medicine. 7 April 2024. Retrieved30 May 2024.
  9. ^Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R (1999)."CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase".Journal of Biological Chemistry.274 (5):2631–2636.doi:10.1074/jbc.274.5.2631.PMID 9915791.
  10. ^Lin PT, Gleeson JG, Corbo JC, et al. (2001)."DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization".J. Neurosci.20 (24):9152–61.doi:10.1523/JNEUROSCI.20-24-09152.2000.PMC 6773030.PMID 11124993.
  11. ^Gerbe F, Legraverend C, Jay P (2012)."The intestinal epithelium tuft cells: specification and function".Cellular and Molecular Life Sciences.69 (17):2907–2917.doi:10.1007/s00018-012-0984-7.PMC 3417095.PMID 22527717.

Further reading

[edit]

External links

[edit]
  • Overview of all the structural information available in thePDB forUniProt:O15075 (Serine/threonine-protein kinase DCLK1) at thePDBe-KB.
PDB gallery
  • 1mfw: STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: SELENOMETHIONINE LABELED PROTEIN
    1mfw: STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: SELENOMETHIONINE LABELED PROTEIN
  • 1mg4: STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN
    1mg4: STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN
  • 1uf0: Solution structure of the N-terminal DCX domain of human doublecortin-like kinase
    1uf0: Solution structure of the N-terminal DCX domain of human doublecortin-like kinase
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
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