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DAPK1

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
DAPK1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1IG1,1JKK,1JKL,1JKS,1JKT,1P4F,1WVX,1WVY,1YR5,2W4J,2W4K,2X0G,2XUU,2XZS,2Y0A,2Y4P,2Y4V,2YAK,3DFC,3DGK,3EH9,3EHA,3F5G,3F5U,3GU4,3GU5,3GU6,3GU7,3GU8,3GUB,3ZXT,4B4L,4PF4,4TL0,4TXC,4UV0,4YO4,4YPD,5AUW,5AUU,5AV1,5AUY,5AUT,5AUX,5AUV,5AUZ,5AV0,5AV4,5AV2,5AV3

Identifiers
AliasesDAPK1, DAPK, death associated protein kinase 1, ROCO3
External IDsOMIM:600831;MGI:1916885;HomoloGene:3626;GeneCards:DAPK1;OMA:DAPK1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for DAPK1
Genomic location for DAPK1
Band9q21.33Start87,497,228bp[1]
End87,708,634bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for DAPK1
Genomic location for DAPK1
Band13 B2|13 32.53 cMStart60,749,761bp[2]
End60,911,005bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • palpebral conjunctiva

  • placenta

  • left ovary

  • middle temporal gyrus

  • parietal pleura

  • corpus epididymis

  • gallbladder

  • pancreatic ductal cell

  • monocyte
Top expressed in
  • saccule

  • lateral septal nucleus

  • otic vesicle

  • left lung lobe

  • olfactory tubercle

  • subiculum

  • genital tubercle

  • piriform cortex

  • pineal gland

  • anterior amygdaloid area
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1612

69635

Ensembl

ENSG00000196730

ENSMUSG00000021559

UniProt

P53355

Q80YE7

RefSeq (mRNA)

NM_001288729
NM_001288730
NM_001288731
NM_004938

NM_001285917
NM_029653
NM_134062

RefSeq (protein)

NP_001275658
NP_001275659
NP_001275660
NP_004929

NP_001272846
NP_083929
NP_598823

Location (UCSC)Chr 9: 87.5 – 87.71 MbChr 13: 60.75 – 60.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 1 is anenzyme that in humans is encoded by theDAPK1gene.[5]

Function

[edit]

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[6]

In melanocytic cells DAPK1 gene expression may be regulated byMITF.[7]

As a drug target

[edit]

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[8] This has not been demonstrated in actual patients.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000196730 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000021559 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively".Genomics.29 (1):305–7.doi:10.1006/geno.1995.1255.PMID 8530096.
  6. ^"Entrez Gene: DAPK1 death-associated protein kinase 1".
  7. ^Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008)."Novel MITF targets identified using a two-step DNA microarray strategy".Pigment Cell & Melanoma Research.21 (6):665–76.doi:10.1111/j.1755-148X.2008.00505.x.PMID 19067971.S2CID 24698373.
  8. ^Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015)."Death-associated protein kinase 1 promotes growth of p53-mutant cancers".The Journal of Clinical Investigation.125 (7):2707–20.doi:10.1172/JCI70805.PMC 4563671.PMID 26075823.

Further reading

[edit]
PDB gallery
  • 1ig1: 1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.
    1ig1: 1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.
  • 1jkk: 2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.
    1jkk: 2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.
  • 1jkl: 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE
    1jkl: 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE
  • 1jks: 1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
    1jks: 1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
  • 1jkt: TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
    1jkt: TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
  • 1p4f: DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
    1p4f: DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
  • 1wvw: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
    1wvw: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
  • 1wvx: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
    1wvx: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
  • 1wvy: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
    1wvy: Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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