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Dual amylin and calcitonin receptor agonists

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(Redirected fromDACRA)

Dual amylin and calcitonin receptor agonists (DACRAs) are a class of drugs that act as agonists at theamylin receptor andcalcitonin receptor that are under development as therapies for obesity and type 2 diabetes. Examples arecagrilintide,Petrelintide,ACCG-2671 and the KBP family derived fromsalmon calcitonin,[1] includingKBP‐042,[2]KBP-066A,[3]KBP-089,[4] andKBP-336.[5]

References

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  1. ^Larsen, A. T.; Mohamed, K. E.; Sonne, N.; Bredtoft, E.; Andersen, F.; Karsdal, M. A.; Henriksen, K. (December 2022)."Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models".Biomedicine & Pharmacotherapy.156 113842.doi:10.1016/j.biopha.2022.113842.ISSN 1950-6007.PMID 36242844.
  2. ^Henriksen, Kim; Broekhuizen, Karen; de Boon, Wadim M. I.; Karsdal, Morten A.; Bihlet, Asger R.; Christiansen, Claus; Dillingh, Marlous R.; de Kam, Marieke; Kumar, Raj; Burggraaf, Jacobus; Kamerling, Ingrid M. C. (December 2021)."Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects".British Journal of Clinical Pharmacology.87 (12):4786–4796.doi:10.1111/bcp.14921.ISSN 0306-5251.PMID 34019711.S2CID 235093884.
  3. ^Andreassen, K. V.; Larsen, A. T.; Sonne, N.; Mohamed, K. E.; Karsdal, M. A.; Henriksen, K. (1 November 2021)."KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats".Molecular Metabolism.53 101282.doi:10.1016/j.molmet.2021.101282.ISSN 2212-8778.PMC 8313742.PMID 34214708.
  4. ^Larsen, Anna Thorsø; Gydesen, Sofie; Sonne, Nina; Karsdal, Morten Asser; Henriksen, Kim (7 January 2021)."The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile".BMC Endocrine Disorders.21 (1): 10.doi:10.1186/s12902-020-00678-2.ISSN 1472-6823.PMC 7791885.PMID 33413317.
  5. ^Melander, Simone A.; Larsen, Anna T.; Elhady Mohamed, Khaled; Karsdal, Morten A.; Henriksen, Kim (20 June 2023)."840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats".Diabetes.72 (Supplement_1).doi:10.2337/db23-840-P.S2CID 259415731.


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