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Cytopenia

From Wikipedia, the free encyclopedia
Medical condition

Cytopenia is a reduction in the number of matureblood cells. It can have many causes, and commonly occurs in people with cancer being treated withradiation therapy orchemotherapy.

Types

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There are also two general causes of cytopenia: autoimmune and refractory. Autoimmune cytopenia is caused by an autoimmune disease when your body produces antibodies to destroy the healthy blood cells. Refractory cytopenia is caused by bone marrow not producing healthy blood cells, and can be a result of cancer.

Symptoms and signs

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The symptoms of cytopenia vary depending on the type.

The symptoms of anemia include:[citation needed]

  • Fatigue
  • Weakness
  • Shortness of breath
  • Poor concentration
  • Dizziness or feeling lightheaded
  • Cold hands or feet[4]

The symptoms of leukopenia include:

  • Frequent infections
  • Fever

The symptoms of thrombocytopenia include:

  • Easily bleeding or bruising
  • Difficulty to stop bleeding
  • Internal bleeding

Causes

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Cytopenias can be caused by anything that decreases the production of blood cells or increases the destruction of blood cells. This includes, but is not limited to:[citation needed]

  • Chemotherapy
  • Malignant tumors
  • Antacids
  • Antibiotics
  • Anticonvulsants
  • Antimalarials
  • Antivirals
  • Cardiac drugs
  • Diabetes drugs
  • Hyperthyroid drugs
  • NSAIDs
  • Rheumatoid arthritis drugs

Treatment

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The treatments for cytopenia vary depending on the type of cytopenia. The treatment for anemia is rest and a diet consisting of high iron foods. Medication can also be used such as:[citation needed]

  • Epoetin alfa, a syntheticerythropoietin that stimulates stem cells to produce red blood cells.
  • Darbepoetin alfa stimulates red blood cells but requires less daily doses and less disruption in activities.
  • Growth factors, synthetic versions of substances involved in stimulating red and white blood cell production, such asG-CSF andGM-CSF.

People with leukopenia are advised to avoid contact with people who are ill, monitor closely for signs of infection, and take antibiotics when appropriate.

Bone marrow and stem cell transplantation are effective for many types of cytopenias. However, when a compatible donor cannot be found,immunosuppressive therapy is also common.[5]

See also

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References

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  1. ^"Leukopenia - MeSH - NCBI".www.ncbi.nlm.nih.gov. Retrieved2019-08-14.
  2. ^"Neutropenia - MeSH - NCBI".www.ncbi.nlm.nih.gov. Retrieved2019-08-14.
  3. ^"Cytopenia Overview, Types - Cytopenia - HealthCommunities.com".www.healthcommunities.com. Retrieved2019-02-26.
  4. ^"Anemia - Symptoms and causes".Mayo Clinic. Retrieved2019-02-26.
  5. ^"Cytopenia Treatment, Prognosis - Cytopenia - HealthCommunities.com".www.healthcommunities.com. Archived fromthe original on 2020-01-18. Retrieved2019-02-26.
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