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Cyclopyrrolones

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Class of chemical hypnotics
Skeletal formula of the parent compound, cyclopyrrolone

Cyclopyrrolones are a family ofhypnotic andanxiolyticnonbenzodiazepine drugs with similar pharmacological profiles to thebenzodiazepine derivatives.

Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via thebenzodiazepine receptor ofneurotransmitterGABA.[1] The best-known cyclopyrrolone derivatives arezopiclone (Imovane) and itsactive single-enantiomer component,eszopiclone (Lunesta), which are used to treatinsomnia, and have a known potential for abuse. Other cyclopyrrolones include:

References

[edit]
  1. ^Jones, Ian R; Sullivan, Gary (January 10, 1998)."Physical dependence on zopiclone: case reports".The BMJ.316 (117).doi:10.1136/bmj.316.7125.117.PMC 2665371. RetrievedApril 21, 2021.
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