Movatterモバイル変換

[0]ホーム

Jump to content

Cyclin-dependent kinase 3

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

"CDK3" redirects here. For the IATA airport code, seeDorset/Kawagama Lake (South) Water Aerodrome.

CDK3

Available structures

PDB

Human UniProt search:PDBe RCSB

List of PDB id codes
1LFN

Identifiers

Aliases

CDK3, cyclin dependent kinase 3

External IDs

OMIM:123828;HomoloGene:74387;GeneCards:CDK3;OMA:CDK3 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.1	Start	76,000,855bp^[1]
Band	17q25.1	End	76,005,999bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

right lobe of liver

granulocyte

pituitary gland

right lobe of thyroid gland

right uterine tube

anterior pituitary

gonad

prostate

spleen

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein kinase activity transferase activity cyclin-dependent protein serine/threonine kinase activity protein binding cyclin binding
Cellular component	cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm
Biological process	cell division cell population proliferation cell cycle G0 to G1 transition cellular response to DNA damage stimulus phosphorylation protein phosphorylation signal transduction multicellular organism development positive regulation of cell population proliferation response to organic substance regulation of G2/M transition of mitotic cell cycle regulation of gene expression G1/S transition of mitotic cell cycle regulation of cell cycle
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1018


n/a

Ensembl


ENSG00000250506


n/a

UniProt


Q00526


n/a

RefSeq (mRNA)


NM_001258


n/a

RefSeq (protein)


NP_001249


n/a

Location (UCSC)

Chr 17: 76 – 76.01 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Cell division protein kinase 3 is anenzyme that in humans is encoded by theCDK3gene.^[3]^[4]

Function

[edit]

CDK3 complements cdc28 mutants ofSaccharomyces cerevisiae suggesting that it may be involved incell cycle control. CDK3 canphosphorylate histone H1 and interacts with an unknown type ofcyclin.^[4]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000250506 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (Aug 1992)."A family of human cdc2-related protein kinases".EMBO J.11 (8):2909–17.doi:10.1002/j.1460-2075.1992.tb05360.x.PMC 556772.PMID 1639063.
^^a ^b"Entrez Gene: CDK3 cyclin-dependent kinase 3".

External links

[edit]

CDK3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
CDK3 human gene location in theUCSC Genome Browser.
CDK3 human gene details in theUCSC Genome Browser.

Cell cycle proteins

Cyclin

A (A1,A2)
B (B1,B2, B3)
D (D1,D2,D3)
E (E1,E2)

CDK

CDK inhibitor

INK4a/ARF (p14arf/p16,p15,p18,p19)
cip/kip (p21,p27,p57)

P53 p63 p73 family

Other

Phases and
checkpoints

Interphase	G₁ phase S phase G₂ phase
M phase	Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis
Cell cycle checkpoints	Restriction point Spindle checkpoint Postreplication checkpoint
Other cellular phases	Apoptosis G₀ phase Meiosis

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

ThisEC 2.7 enzyme-related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Cyclin-dependent_kinase_3&oldid=1301317912"

Categories:

Hidden categories:

[8]ページ先頭

Movatterモバイル変換

Function

References

Further reading

External links