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Cyclic nucleotide-gated channel alpha 2

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CNGA2

Identifiers

Aliases

CNGA2, CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa, Cyclic nucleotide-gated channel alpha 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2

External IDs

OMIM:300338;MGI:108040;HomoloGene:32022;GeneCards:CNGA2;OMA:CNGA2 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq28	Start	151,734,746bp^[1]
Band	Xq28	End	151,745,564bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A7.3	Start	71,035,455bp^[2]
Band	X\|X A7.3	End	71,053,824bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

left testis

Top expressed in

olfactory epithelium

urethra

embryo

secondary oocyte

zygote

primary oocyte

entorhinal cortex

central gray substance of midbrain

superior frontal gyrus

thymus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding cAMP binding calmodulin binding ion channel activity voltage-gated potassium channel activity intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity cGMP binding
Cellular component	integral component of membrane membrane Golgi membrane ciliary membrane Golgi-associated vesicle membrane integral component of plasma membrane
Biological process	response to stimulus regulation of membrane potential ion transport sensory perception of smell ion transmembrane transport transmembrane transport potassium ion transmembrane transport cation transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1260


12789

Ensembl


ENSG00000183862


ENSMUSG00000005864

UniProt


Q16280


Q62398

RefSeq (mRNA)


NM_005140


NM_007724

RefSeq (protein)


NP_005131


NP_031750

Location (UCSC)

Chr X: 151.73 – 151.75 Mb

Chr X: 71.04 – 71.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclic nucleotide gated channel alpha 2, also known asCNGA2, is a humangene encoding anion channel protein.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000183862 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000005864 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: CNGA2 cyclic nucleotide gated channel alpha 2".

External links

[edit]

CNGA2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin