Corymine and related alkaloids can act asconvulsants.[2]
Tests onXenopus occyte species have shown that corymine can decreaseglycine's action at the inhibitoryglycine receptors.[3] These same tests have revealed that Corymine can reduce the response ofreceptors toGABA,[3] the primary inhibitory neurotransmitter.
Other experiments have shown that corymine can potentiate convulsions induced bystrychnine, a potentglycine antagonist.[4] This was also observed in mice.[5]
^abLeewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, et al. (August 1997). "Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes".European Journal of Pharmacology.332 (3):321–326.doi:10.1016/s0014-2999(97)01097-2.PMID9300267.
^Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, et al. (May 1998). "A possible mechanism underlying corymine inhibition of glycine-induced Cl- current in Xenopus oocytes".European Journal of Pharmacology.348 (2–3):271–277.doi:10.1016/s0014-2999(98)00147-2.PMID9652343.
^Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, et al. (March 1996). "Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica".Biological & Pharmaceutical Bulletin.19 (3):394–399.doi:10.1248/bpb.19.394.PMID8924908.
