| Coronavirus frameshifting stimulation element | |
|---|---|
 Predictedsecondary structure andsequence conservation of Corona_FSE | |
| Identifiers | |
| Symbol | Corona_FSE |
| Rfam | RF00507 |
| Other data | |
| RNA type | Cis-reg;frameshift element |
| Domain | Viruses |
| SO | SO:0001427 |
| PDB structures | PDBe |
Inmolecular biology, thecoronavirusframeshifting stimulation element is aconservedstem-loop ofRNA found incoronaviruses that can promoteribosomal frameshifting. Such RNA molecules interact with adownstream region to form apseudoknot structure; the region varies according to the virus but pseudoknot formation is known to stimulateframeshifting. In the classical situation, a sequence 32nucleotides downstream of the stem is complementary to part of the loop. In other coronaviruses, however, another stem-loop structure around 150 nucleotides downstream can interact with members of this family to formkissing stem-loops and stimulate frameshifting.[1]
Other RNA families identified in the coronavirus include thecoronavirus 3′ stem-loop II-like motif (s2m), thecoronavirus packaging signal and thecoronavirus 3′ UTR pseudoknot.
During protein synthesis, rapidly changing conditions in the cell can causeribosomal pausing. In coronaviruses, this can affect growth rate and trigger translational abandonment. This releases the ribosome from the mRNA and the incomplete polypeptide is targeted for destruction.[2]
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