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Coronary reflex

From Wikipedia, the free encyclopedia

Coronary reflex is the change of coronary diameter in response to chemical, neurological or mechanical stimulation of thecoronary arteries.The coronary reflexes are stimulated differently from the rest of thevascular system.[citation needed]

Causes of coronary constriction

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Chemical

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  • N-nitroL-arginine
  • indomethacin
  • glibenclamide
  • tetraethylammonium chloride
  • caffeine

Other

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  • Cold

Causes of coronary dilation

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Cocaine abuse frequently can cause a coronary spasm, resulting in a spontaneousmyocardial infarction.[citation needed]

Chemical

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  • Versed (Midazolam): a coronary dilator. In midazolam's presence, dilation was unaffected by N-nitro L-arginine, indomethacin and glibenclamide.
  • Tetraethylammonium chloride, an inhibitor of the BKCa K+ channel (a high conductance Ca2+-sensitive K+ channel), dose dependently attenuated the vasodilating effect ofmidazolam[1]
  • Estrogen has been shown to abolish abnormal cold-induced coronary constriction.[2]

References

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  1. ^O.L. Woodman; G.J. Dusting (1991)."N-nitro L-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds".Br. J. Pharmacol.103 (2):1407–1410.doi:10.1111/j.1476-5381.1991.tb09802.x.PMC 1908370.PMID 1909199.
  2. ^Steven E. Reis, MD; Richard Holubkov; Kathleen A. Zell, BSN; AJ. Conrad Smith, MD; Howard A. Cohen, MD; Marc D. Feldman, MD; Roger S. Blumenthal, MD (1998)."Estrogen Acutely Abolishes Abnormal Cold-Induced Coronary Constriction in Men*".Chest.114 (6):1556–1561.doi:10.1378/chest.114.6.1556.PMID 9872188.
Cranial nerve
Stretch reflexes
Primitive reflexes
Superficial reflexes
Cardiovascular
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